Protein Alignment HPN and CG11841

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_651661.1
• Gene: CG11841 / 43430
• FlyBaseID: FBgn0039628
• Length: 319
• Species: Drosophila melanogaster
• Alignment Length: 352
• Identity: 93/352 - (26%)
• Similarity: 132/352 - (37%)
• Gaps: 78/352 - (22%)

Human    75 LLCSSRSNARVAGLSCEEMGFLRALTHSEL--DVRTAGANGTSGFFCVDEGRLPHTQRLLEVISV 137
            ||..|.|::.|.|.:.:....|......::  :.|.|     ..||..|   .|.|   .|.:..
  Fly    11 LLVFSLSSSLVQGQNPDPFAQLACTKFKQIVFEERVA-----ISFFFTD---APIT---YETVDS 64

Human   138 CDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAH-----LCGGSLLSGDW 197
            |.              |.|.|    ||.|.......:|:...|.:...:     .|||:|:|...
  Fly    65 CH--------------GSRPL----IVDGTPAEPKEFPFAARLGHRKTNNEIKWFCGGTLISNRL 111

Human   198 VLTAAHCFPERNRVLSRWRV----FAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDI 258
            ||||||||...:..::..|:    |......|.|.  ..||.|:..|.|   |.:|   :..|||
  Fly   112 VLTAAHCFFSEHGEVNVVRLGELEFDTDTDDAEPE--DFGVLALKAHPG---FENP---QLYNDI 168

Human   259 ALVHLSSPLPLTEYIQPVCLPAAGQALVDG---KICTVTGWGNTQYYGQQAGVLQEARVPIISND 320
            .:|.|...:....|..|.|||     ..||   :.....|||..::..:::..|.:.::... .|
  Fly   169 GIVQLDREVKFNRYKHPACLP-----FDDGEQHESFIAIGWGQKKFAQKESKKLLKVQLQGY-KD 227

Human   321 VC----NGADFYGNQIKPK-MFCAGYPEGGIDACQGDSGGP-------FVCEDSISRTPRWRLCG 373
            .|    :..|...|..:|| ..|.|..:.. |.|.||||||       ..|        .:.:.|
  Fly   228 RCVSSVDANDELPNGYEPKSQLCIGSRDNK-DTCNGDSGGPVLAYHKDLAC--------MYHVMG 283

Human   374 IVSWGTGCALAQKPGVYTKVSDFREWI 400
            |.|.|..|:....|..||:|..|..||
  Fly   284 ITSAGITCSTPDIPSAYTRVHYFLNWI 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	18/85 (21%)
		Tryp_SPc	163..400	CDD:238113	72/260 (28%)
CG11841	NP_651661.1	Tryp_SPc	72..311	CDD:238113	74/262 (28%)