Protein Alignment HPN and CG5909

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_651544.1
• Gene: CG5909 / 43274
• FlyBaseID: FBgn0039495
• Length: 381
• Species: Drosophila melanogaster
• Alignment Length: 424
• Identity: 106/424 - (25%)
• Similarity: 160/424 - (37%)
• Gaps: 83/424 - (19%)

Human    19 AALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSADARLM---VFDKTEGTW------- 73
            ||:..|.||          .|:..|:.|....:.|.|.:....|..   ...|..|.:
  Fly     4 AAIRLGLLL----------CILPQLVISQSSCVTPAQAAGQCIRYQECPFVQKILGIYGRNIPRK 58

Human    74 ------RLLCSSRSNARVAGLSCEEMGFLRALTHSELD-VRTAGANGTSGFFCVDEGRLPHTQRL 131
                  .:.|.|.:|.|...|.|......::...|:.. ||:.|            |.|....|
  Fly    59 IHNQISEMQCRSTTNTRDFHLCCPNEAPPQSNQESQRKVVRSEG------------GNLNRYDR- 110

Human   132 LEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRY----DGAHLCGGSL 192
                      :|..|.....:||.:..|  ::.||:....|.:||...|:|    .....|||||
  Fly   111 ----------QGLQLLNSVTNCGNKGNP--KVSGGKTARPGDFPWVALLKYKINDPRPFRCGGSL 163

Human   193 LSGDWVLTAAHCFPERNRVLS------------RWRVFAGAVAQASPHGLQLGVQAVVYHGGYLP 245
            :|...:||||||..::..|::            ......|......|...:.|::.:..|..|:
  Fly   164 ISERHILTAAHCIIDQPEVIAVRLGEHDLESEEDCHYLGGTNRVCIPPYEEYGIEQIRVHPNYV- 227

Human   246 FRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLP--AAGQALVDGKICTVTGWGNTQYYGQQAGV 308
                 ..:.|:|:|::.|...:....:|:|||||  ...|.|...:...|.|||.|: ....|..
  Fly   228 -----HGKISHDVAIIKLDRVVKEKSHIKPVCLPIDQKSQELDFDQSFFVAGWGGTE-KETVATK 286

Human   309 LQEARVPIISNDVCNGADFYG-NQIKPKMFCAGYPEGGI-DACQGDSGGPFVCEDSISRTPRWRL 371
            ||:|.:...|.:.|.  .:|. .::.....||  ...|| ..||||||||...:.....|.|...
  Fly   287 LQQALITRKSLNECR--QYYNKGEVSDNHICA--TGTGIKHTCQGDSGGPVFFKHRFKNTYRVVQ 347

Human   372 CGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIK 405
            .|:||:|.......:|||:..|.|...||.|.::
  Fly   348 YGVVSFGGRLCGQNQPGVFASVIDMLPWITQNLQ 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	22/124 (18%)
		Tryp_SPc	163..400	CDD:238113	72/256 (28%)
CG5909	NP_651544.1	CLIP	25..82	CDD:197829	10/56 (18%)
		Tryp_SPc	132..379	CDD:238113	74/257 (29%)