Protein Alignment HPN and CG11836

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_001356925.1
• Gene: CG11836 / 43007
• FlyBaseID: FBgn0039272
• Length: 333
• Species: Drosophila melanogaster
• Alignment Length: 295
• Identity: 105/295 - (35%)
• Similarity: 156/295 - (52%)
• Gaps: 34/295 - (11%)

Human   111 ANGTSGFFCVD--EGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGR 173
            ::|.|..|.:.  |..:.:|:.  ..:..|||           |||.....: |||||:.|.:.:
  Fly    57 SSGVSNAFGLSDTEDEVEYTEN--SSLKNCDC-----------DCGFSNEEI-RIVGGKPTGVNQ 107

Human   174 WPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQ---ASPHGLQLGVQ 235
            :||...:.|||...||||||:.|:||:||||..:..:  |:.||..|...|   :....:|..|.
  Fly   108 YPWMARIVYDGKFHCGGSLLTKDYVLSAAHCVKKLRK--SKIRVIFGDHDQEITSESQAIQRAVT 170

Human   236 AVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ 300
            ||:.|..:    ||::  .:|||||:.|..|:..::.|:|:|||....... |:|.||.|||.|.
  Fly   171 AVIKHKSF----DPDT--YNNDIALLRLRKPISFSKIIKPICLPRYNYDPA-GRIGTVVGWGRTS 228

Human   301 YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISR 365
            ..|:...::.:.:|||:|...|....:...:|...|.|||.|  .:|:||||||||.:..:.:
  Fly   229 EGGELPSIVNQVKVPIMSITECRNQRYKSTRITSSMLCAGRP--SMDSCQGDSGGPLLLSNGV-- 289

Human   366 TPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWI 400
              ::.:.||||||.||.....||||::||.|..||
  Fly   290 --KYFIVGIVSWGVGCGREGYPGVYSRVSKFIPWI 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	11/49 (22%)
		Tryp_SPc	163..400	CDD:238113	91/239 (38%)
CG11836	NP_001356925.1	Tryp_SPc	97..325	CDD:238113	93/241 (39%)