Protein Alignment HPN and CG5246

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_650603.1
• Gene: CG5246 / 42072
• FlyBaseID: FBgn0038484
• Length: 272
• Species: Drosophila melanogaster
• Alignment Length: 250
• Identity: 79/250 - (31%)
• Similarity: 122/250 - (48%)
• Gaps: 30/250 - (12%)

Human   159 PVDRIVGGRDTSLGRWPWQVSLRYD-GAHLCGGSLLSGDWVLTAAHCFPERNRVLSRW-----RV 217
            |..|::||.|:..|..|:|||:... |.|:||||:::..|:||||||.        .|     ::
  Fly    38 PETRVIGGVDSPTGFAPYQVSIMNTFGEHVCGGSIIAPQWILTAAHCM--------EWPIQYLKI 94

Human   218 FAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAG 282
            ..|.|....| |.:..|.....|..:      :.....|||||:|.:.|:...:..||:.|.:.|
  Fly    95 VTGTVDYTRP-GAEYLVDGSKIHCSH------DKPAYHNDIALIHTAKPIVYDDLTQPIKLASKG 152

Human   283 QALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGID 347
            .....|...|:||||:|:.:|:.:..||:..:..|.:|.|.......|.:.....|. :.:.|..
  Fly   153 SLPKVGDKLTLTGWGSTKTWGRYSTQLQKIDLNYIDHDNCQSRVRNANWLSEGHVCT-FTQEGEG 216

Human   348 ACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQ 402
            :|.||||||.|   ..::|    |.|:|:||..||:.. |.|:..|:.:.:||.|
  Fly   217 SCHGDSGGPLV---DANQT----LVGVVNWGEACAIGY-PDVFGSVAYYHDWIEQ 263

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	78/249 (31%)
		Tryp_SPc	163..400	CDD:238113	74/242 (31%)
CG5246	NP_650603.1	Tryp_SPc	42..263	CDD:238113	76/244 (31%)