Protein Alignment HPN and Sb

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_476709.1
• Gene: Sb / 41958
• FlyBaseID: FBgn0003319
• Length: 787
• Species: Drosophila melanogaster
• Alignment Length: 371
• Identity: 129/371 - (34%)
• Similarity: 179/371 - (48%)
• Gaps: 49/371 - (13%)

Human    53 PVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAG--ANGTS 115
            |...:|:.:......||..|.|.:.||.|::  :|:........:. ||....:.|:|  .|..|
  Fly   448 PTTATSSSSTSTTSSKTPTTTRPISSSSSSS--SGIVTSSQRPTQP-THRTPVLATSGIETNEIS 509

Human   116 GFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL 180
            .....|.|.|.|.:.:....|.|..|.   ||.          |..|||||:..:.||||||||:
  Fly   510 DSSIPDAGALGHVKTISAARSECGVPT---LAR----------PETRIVGGKSAAFGRWPWQVSV 561

Human   181 R------YDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGA-----VAQASPHGLQLGV 234
            |      :...|.|||:|::.:|:.||.||..:  .::|:.|:..|.     |.:..|: ::.||
  Fly   562 RRTSFFGFSSTHRCGGALINENWIATAGHCVDD--LLISQIRIRVGEYDFSHVQEQLPY-IERGV 623

Human   235 QAVVYHGGY--LPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWG 297
            ...|.|..|  |.:        ..|:|||.|..||....::.|:|||.....|: |...||||||
  Fly   624 AKKVVHPKYSFLTY--------EYDLALVKLEQPLEFAPHVSPICLPETDSLLI-GMNATVTGWG 679

Human   298 NTQYYGQQAGVLQEARVPIISNDVCNGADFYG--NQIKPKMF-CAGYPEGGIDACQGDSGGPFVC 359
            .....|....||||..|||:|||.|.......  .:..|.:| ||||..||.|:||||||||...
  Fly   680 RLSEGGTLPSVLQEVSVPIVSNDNCKSMFMRAGRQEFIPDIFLCAGYETGGQDSCQGDSGGPLQA 744

Human   360 EDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIK 405
            :   |:..|:.|.||:|||.|||.|..|||.|::|.|..||.:.::
  Fly   745 K---SQDGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWILEHVR 787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	25/107 (23%)
		Tryp_SPc	163..400	CDD:238113	100/252 (40%)
Sb	NP_476709.1	Tryp_SPc	544..785	CDD:238113	102/255 (40%)