Protein Alignment HPN and ea

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_524362.2
• Gene: ea / 41858
• FlyBaseID: FBgn0000533
• Length: 392
• Species: Drosophila melanogaster
• Alignment Length: 337
• Identity: 102/337 - (30%)
• Similarity: 149/337 - (44%)
• Gaps: 64/337 - (18%)

Human   125 LPHTQRLLEVISVCDCPRGRFLAAICQDCGRRK-----------------LPV---------DRI 163
            |..|.||....|.|....|:.|.. |.|..|..                 ||:         :||
  Fly    65 LRDTDRLYLSRSQCGYTNGKVLIC-CPDRYRESSSETTPPPKPNVTSNSLLPLPGQCGNILSNRI 128

Human   164 VGGRDTSLGRWPWQVSLRYDGA-----HLCGGSLLSGDWVLTAAHC-----FPERNRV----LSR 214
            .||..|.:..:||...:.|..:     |.|||||:|..:|:||:||     .|...|:    |..
  Fly   129 YGGMKTKIDEFPWMALIEYTKSQGKKGHHCGGSLISTRYVITASHCVNGKALPTDWRLSGVRLGE 193

Human   215 W--------RVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTE 271
            |        .|....:...:|..|.:.|:..:.|..|:    |.|:...|||||:.|:..:..|:
  Fly   194 WDTNTNPDCEVDVRGMKDCAPPHLDVPVERTIPHPDYI----PASKNQVNDIALLRLAQQVEYTD 254

Human   272 YIQPVCLPA---AGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQ-- 331
            :::|:|||.   ...|..||....|.|||.|:.. ..:.:..:|.|.....|.|.  :.|.:|
  Fly   255 FVRPICLPLDVNLRSATFDGITMDVAGWGKTEQL-SASNLKLKAAVEGFRMDECQ--NVYSSQDI 316

Human   332 -IKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWG-TGCALAQKPGVYTKVS 394
             ::....|||..| |:|:|:||||||.:..|:......:.|.|:||:| |.|.||..|||||.|.
  Fly   317 LLEDTQMCAGGKE-GVDSCRGDSGGPLIGLDTNKVNTYYFLAGVVSFGPTPCGLAGWPGVYTLVG 380

Human   395 DFREWIFQAIKT 406
            .:.:||...|::
  Fly   381 KYVDWIQNTIES 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	11/50 (22%)
		Tryp_SPc	163..400	CDD:238113	85/265 (32%)
ea	NP_524362.2	CLIP	37..89	CDD:463440	8/24 (33%)
		Tryp_SPc	128..389	CDD:238113	87/268 (32%)