Protein Alignment HPN and CG8870

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_731802.1
• Gene: CG8870 / 41645
• FlyBaseID: FBgn0038144
• Length: 356
• Species: Drosophila melanogaster
• Alignment Length: 348
• Identity: 101/348 - (29%)
• Similarity: 143/348 - (41%)
• Gaps: 89/348 - (25%)

Human   111 ANGTSGFF---CVDEGRLPHTQRLL-----EVISVCDCPRGRFLAAIC----------QDCGR-R 156
            :||....|   ||:..:.|.|:.::     .:|.:..|...:    :|          ..||: |
  Fly    21 SNGAGCQFDTECVNLDKCPRTRAVMNSSRKNIIGLRRCGTNK----VCCPKWETYLPHDTCGQSR 81

Human   157 KLPVDRIVGGRDTSLGRWPWQVSLRYDGAH--------LCGGSLLSGDWVLTAAHC-------FP 206
            :.|..    |:..:|..:||...|.|...:        .|||||::..:|||||||       :|
  Fly    82 RKPTK----GKIPALNEFPWMAMLLYGNKNNLSQKLVPKCGGSLINNWYVLTAAHCVEYPFMDYP 142

Human   207 ---------ERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVH 262
                     |.|...:..|.......|.:|..:::.|..::.|..:     .......||||||.
  Fly   143 YALKTVRLGEHNTSTNPDRAIVNGRRQYAPLYMEIEVDQIITHEQF-----NRGRRLINDIALVR 202

Human   263 LSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEA--------RVPIISN 319
            |..|:..|..|||:|||.|.:.....:....:||.:   .||  |:..|.        |.|
  Fly   203 LKFPVRYTRAIQPICLPRAQKLAAHKRKFQASGWPD---MGQ--GIASEVLLRSFIAERHP---- 258

Human   320 DVC-NGADF-YGNQIKPKMFCAGYPEGGIDACQGDSGGPF---VCEDSISRTPRWRLCGIVSWG- 378
            ||| :..|| .|:||     |||..:|. |...||||||.   |....::.|   ...||:|:|
  Fly   259 DVCKSNYDFNLGSQI-----CAGGLDGN-DTSPGDSGGPLMETVIRGKVTLT---YAAGIISYGQ 314

Human   379 TGCALAQ-KPGVYTKVSDFREWI 400
            ..|.|.. ||..|||.|.|.|||
  Fly   315 KPCVLKTCKPAFYTKTSYFFEWI 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	13/66 (20%)
		Tryp_SPc	163..400	CDD:238113	85/275 (31%)
CG8870	NP_731802.1	Tryp_SPc	93..340	CDD:238113	85/268 (32%)