Protein Alignment HPN and snk

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_524338.2
• Gene: snk / 41607
• FlyBaseID: FBgn0003450
• Length: 435
• Species: Drosophila melanogaster
• Alignment Length: 378
• Identity: 106/378 - (28%)
• Similarity: 162/378 - (42%)
• Gaps: 91/378 - (24%)

Human   103 ELDVRTA-------GA------NGTSGFFCVDEGRLPHTQRLLEV----ISVCD---------CP 141
            :.:|||:       ||      :|.|| :|:...:..|..|...|    |.:|.         ||
  Fly    76 DAEVRTSVSEGLHEGAFCRRSFDGRSG-YCILAYQCLHVIREYRVHGTRIDICTHRNNVPVICCP 139

Human   142 RG-------RFLAAICQD-----------------CGRRKLP-VDRIVGGRDTSLGRWPWQVSLR 181
            ..       |..|..||:                 .|::.:| |..||||..|..|.:|...:|.
  Fly   140 LADKHVLAQRISATKCQEYNAAARRLHLTDTGRTFSGKQCVPSVPLIVGGTPTRHGLFPHMAALG 204

Human   182 Y---------DGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAV 237
            :         |....|||:|:|..:|||||||....::.....|:.|..:.:.|.....:.:..:
  Fly   205 WTQGSGSKDQDIKWGCGGALVSELYVLTAAHCATSGSKPPDMVRLGARQLNETSATQQDIKILII 269

Human   238 VYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTV--TGWGNTQ 300
            |.|..|      .|....:||||:.|:..:..:|.::|.||    ..|.:.:|.||  .|||.|:
  Fly   270 VLHPKY------RSSAYYHDIALLKLTRRVKFSEQVRPACL----WQLPELQIPTVVAAGWGRTE 324

Human   301 YYGQQAGVLQEARVPIISNDVCNGADFYGNQIK-PK-----MFCAGYPEGGIDACQGDSGGPFVC 359
            :.|.::..|::..:.::....|.  ..|..:.: |:     .|||||..||.|.||||||||.
  Fly   325 FLGAKSNALRQVDLDVVPQMTCK--QIYRKERRLPRGIIEGQFCAGYLPGGRDTCQGDSGGPI-- 385

Human   360 EDSISRTPRWR----LCGIVSWGTGCALAQKPGVYTKVSDFREWIFQ-AIKTH 407
               .:..|.:.    :.||.|:|..||....|||||::..:.:||.: |.|.|
  Fly   386 ---HALLPEYNCVAFVVGITSFGKFCAAPNAPGVYTRLYSYLDWIEKIAFKQH 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	21/105 (20%)
		Tryp_SPc	163..400	CDD:238113	78/257 (30%)
snk	NP_524338.2	CLIP	93..139	CDD:197829	9/46 (20%)
		Tryp_SPc	186..430	CDD:238113	80/260 (31%)