Protein Alignment HPN and CG12951

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_649880.1
• Gene: CG12951 / 41110
• FlyBaseID: FBgn0037677
• Length: 265
• Species: Drosophila melanogaster
• Alignment Length: 262
• Identity: 90/262 - (34%)
• Similarity: 132/262 - (50%)
• Gaps: 40/262 - (15%)

Human   154 GRRKLPVDRIVGGRDTSLGRWPWQVSLR-YDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRV 217
            |:....:.|:|.|.|:|:.::|:.|||| |||:|.||||::|..:|:|||||  ...|......:
  Fly    21 GQAAPSISRVVNGTDSSVLKYPFVVSLRSYDGSHSCGGSIISKHFVMTAAHC--TNGRPADTLSI 83

Human   218 FAGA--VAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEY----IQPV 276
            ..|.  ::...|:  .:|::.::.|..:.|.|     :|:|||:|:.:..|.   |:    :.||
  Fly    84 QFGVTNISAMGPN--VVGIKKIIQHEDFDPTR-----QNANDISLLMVEEPF---EFDGVSVAPV 138

Human   277 CLPAAGQAL------VDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPK 335
            .|||...|:      |:|   .:.|||....||.....|||..:.|.|::.|...  :..|..||
  Fly   139 ELPALAFAVPQSDAGVEG---VLIGWGLNDTYGSVQDTLQEVSLKIYSDEECTSR--HNGQTDPK 198

Human   336 M-FCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWG-TGCALAQKPGVYTKVSDFRE 398
            . .|.|..|||...|.||||||.:...        :..|||||. ..|.:|..||||.|||.:.:
  Fly   199 YHICGGVDEGGKGQCSGDSGGPLIYNG--------QQVGIVSWSIKPCTVAPYPGVYCKVSQYVD 255

Human   399 WI 400
            ||
  Fly   256 WI 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	1/4 (25%)
		Tryp_SPc	163..400	CDD:238113	86/251 (34%)
CG12951	NP_649880.1	Tryp_SPc	30..260	CDD:238113	88/253 (35%)