Protein Alignment HPN and CG9372

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_649132.1
• Gene: CG9372 / 40137
• FlyBaseID: FBgn0036891
• Length: 408
• Species: Drosophila melanogaster
• Alignment Length: 419
• Identity: 118/419 - (28%)
• Similarity: 177/419 - (42%)
• Gaps: 77/419 - (18%)

Human    37 WAIVAVLLRSDQEPLYPVQVSSADARLMVF-DKTEGTW----RLLCSSRS--NARVAGLSCEEMG 94
            ||:| :||....:......||:....|:.| |..|..|    ..:..:|:  |..|:.||...:.
  Fly     6 WALV-ILLGYIPQSTIAKTVSTDFLDLLDFSDNDEFQWGESENQVYENRTGENRVVSFLSQHRLN 69

Human    95 FLRALTHSELDVRTAGA----NGTSG-----FFCVDEGRLPHTQR----------LLEVISVCDC 140
            ..:|.|...|:.:..||    .|.||     .:|    |:|..:.          ::|..|:..|
  Fly    70 KRQAPTSQLLENKDYGACSTPLGESGRCRHIIYC----RMPELKNDVWRLVSQLCIIEKSSIGIC 130

Human   141 -----PRGRFLAAIC----------------QDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDG 184
                 ...||...:.                :.||.......|:.|||......|||..:|..:|
  Fly   131 CTDQSTSNRFSPQVVTSADGDEPRIVNKPEQRGCGITSRQFPRLTGGRPAEPDEWPWMAALLQEG 195

Human   185 AHL--CGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGL------QLGVQAVVYHG 241
            ...  |||.|::...|||||||..::|:.    .:|. .:.:.:.|.|      ...:..:|.|.
  Fly   196 LPFVWCGGVLITDRHVLTAAHCIYKKNKE----DIFV-RLGEYNTHMLNETRARDFRIANMVLHI 255

Human   242 GYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQA 306
            .|      |.:...||||:|.:........||.|||:|...:...| :...|||||..::.|..:
  Fly   256 DY------NPQNYDNDIAIVRIDRATIFNTYIWPVCMPPVNEDWSD-RNAIVTGWGTQKFGGPHS 313

Human   307 GVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRL 371
            .:|.|..:|:.....|..:  :...:.....|||:||||.|:||||||||.:.:   ....||..
  Fly   314 NILMEVNLPVWKQSDCRSS--FVQHVPDTAMCAGFPEGGQDSCQGDSGGPLLVQ---LPNQRWVT 373

Human   372 CGIVSWGTGCALAQKPGVYTKVSDFREWI 400
            .||||||.||....:||:||:|..:.:||
  Fly   374 IGIVSWGVGCGQRGRPGIYTRVDRYLDWI 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	30/154 (19%)
		Tryp_SPc	163..400	CDD:238113	80/244 (33%)
CG9372	NP_649132.1	CLIP	87..132	CDD:197829	9/48 (19%)
		Tryp_SPc	173..402	CDD:214473	81/245 (33%)