Protein Alignment HPN and CG6865

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_001246825.1
• Gene: CG6865 / 40050
• FlyBaseID: FBgn0036817
• Length: 285
• Species: Drosophila melanogaster
• Alignment Length: 294
• Identity: 92/294 - (31%)
• Similarity: 142/294 - (48%)
• Gaps: 39/294 - (13%)

Human   131 LLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSG 195
            ::.|:|:..|.:.: :|...|.|..|.   .:||||.:......|:.|||...|.|.|||:::|.
  Fly     7 VVAVLSLVKCAQSQ-IAFSNQPCSVRN---PKIVGGSEAERNEMPYMVSLMRRGGHFCGGTIISE 67

Human   196 DWVLTAAHCFPERNRVLSRWRVFAGAVAQAS-----------PHGLQLGVQAVVYHGGYLPFRDP 249
            .|:|||.||.....:...:.....|.|...|           |..|::..:.:|.|..|
  Fly    68 RWILTAGHCICNGLQQFMKPAQIQGVVGLHSIREYLNGIGNGPDALRVDFKNIVPHPQY------ 126

Human   250 NSEENSNDIALVHLSSPLPLTEYIQPVCLPA-AGQALVDGKICTVTGWGNT---QYYGQQAGVLQ 310
            :..:..:||||:.|..|:..:.:|||.|:.: .|...::.:..||:|||.|   |....::.||:
  Fly   127 DCNDVKHDIALLELVQPIRFSSHIQPSCVGSEEGHRSLEQEYGTVSGWGWTHENQAENDRSDVLR 191

Human   311 EARVPIISNDVCNGADFY-----GNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWR 370
            :|.|.|.:|:.|..:  |     .|.|.....||||..|.||:|..|||||.:.::.       .
  Fly   192 KATVKIWNNEACERS--YRSLGKSNTIGETQLCAGYENGQIDSCWADSGGPLMSKEH-------H 247

Human   371 LCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAI 404
            |.|:||.|.|||....||:||:||.:..|:.:.|
  Fly   248 LVGVVSTGIGCARPGLPGIYTRVSKYVSWMQKVI 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	7/27 (26%)
		Tryp_SPc	163..400	CDD:238113	83/256 (32%)
CG6865	NP_001246825.1	Tryp_SPc	34..276	CDD:214473	83/256 (32%)