Protein Alignment HPN and Jon74E

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_001189126.2
• Gene: Jon74E / 39959
• FlyBaseID: FBgn0023197
• Length: 271
• Species: Drosophila melanogaster
• Alignment Length: 278
• Identity: 81/278 - (29%)
• Similarity: 122/278 - (43%)
• Gaps: 35/278 - (12%)

Human   142 RGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAH----LCGGSLLSGDWVLTAA 202
            :||.::  |.|.|..  ...||.||......::|:||.|..:..:    .||.||:|..::||||
  Fly    15 QGRSIS--CLDMGHG--IGGRIAGGELARANQFPYQVGLSIEEPNDMYCWCGASLISDRYLLTAA 75

Human   203 HCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVY-HGGYLPFRDPNSEENSNDIALVHLSSP 266
            ||..:...:    ..:.|.|.:.:|..|.......|: |      .|.|.:...||||||.|...
  Fly    76 HCVEKAVAI----TYYLGGVLRLAPRQLIRSTNPEVHLH------PDWNCQSLENDIALVRLPED 130

Human   267 LPLTEYIQPVCLP--AAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVP---IISNDVCNGAD 326
            ..|.:.|:|:.||  ::.:...|......:|||...  .:...:....|..   :.||:.|..:
  Fly   131 ALLCDSIRPIRLPGLSSSRNSYDYVPAIASGWGRMN--DESTAISDNLRYVYRFVESNEDCEYS- 192

Human   327 FYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWG--TGCALAQKPGV 389
             |.| |||...|.. ..||...|.||||||.|..|.:....  .|.|:.|:|  :||.... |.|
  Fly   193 -YAN-IKPTNICMD-TTGGKSTCTGDSGGPLVYSDPVQNAD--ILIGVTSYGKKSGCTKGY-PSV 251

Human   390 YTKVSDFREWIFQAIKTH 407
            :|:::.:.:||.:....|
  Fly   252 FTRITAYLDWIGEVSGVH 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	5/16 (31%)
		Tryp_SPc	163..400	CDD:238113	72/248 (29%)
Jon74E	NP_001189126.2	Tryp_SPc	31..262	CDD:214473	73/249 (29%)