Protein Alignment HPN and CG11529

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_648558.1
• Gene: CG11529 / 39395
• FlyBaseID: FBgn0036264
• Length: 287
• Species: Drosophila melanogaster
• Alignment Length: 272
• Identity: 82/272 - (30%)
• Similarity: 121/272 - (44%)
• Gaps: 52/272 - (19%)

Human   159 PVDRIVGGRDTSLGR---WPWQVSL----RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWR 216
            |.|....|: :..||   :|:||.|    .:....||||:||...|:|||.||    ...::.:.
  Fly    24 PTDSYAVGQ-SKYGRIEKFPYQVMLIGKQLWRKRILCGGTLLDKRWILTAGHC----TMGVTHYD 83

Human   217 VFAGAVAQASPH---GLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCL 278
            |:.|..:.....   ||.|.....:.|..:      |.|..:||||||.|...:..|..|||..|
  Fly    84 VYLGTKSVEDTEVSGGLVLRSNKFIVHERF------NPETAANDIALVKLPQDVAFTPRIQPASL 142

Human   279 PA-------AGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKM 336
            |:       ||.::|      .:||| .......:..:|...:.:|||..|  |..| :.:...:
  Fly   143 PSRYRHDQFAGMSVV------ASGWG-AMVEMTNSDSMQYTELKVISNAEC--AQEY-DVVTSGV 197

Human   337 FCAGYPEGGID--ACQGDSGGPFVCEDSISRTPRWRLCGIVSWG--TGCALAQKPGVYTKVSDFR 397
            .||   :|..|  .|.||||||.|.:|:      ..:.||.|:|  .||. ...||.:|:|:.:.
  Fly   198 ICA---KGLKDETVCTGDSGGPLVLKDT------QIVVGITSFGPADGCE-TNIPGGFTRVTHYL 252

Human   398 EWIFQAIKTHSE 409
            :||...|.:|.:
  Fly   253 DWIESKIGSHGQ 264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	82/272 (30%)
		Tryp_SPc	163..400	CDD:238113	76/257 (30%)
CG11529	NP_648558.1	Tryp_SPc	37..258	CDD:238113	76/250 (30%)