Protein Alignment HPN and CG6592

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_648016.1
• Gene: CG6592 / 38687
• FlyBaseID: FBgn0035669
• Length: 438
• Species: Drosophila melanogaster
• Alignment Length: 426
• Identity: 113/426 - (26%)
• Similarity: 170/426 - (39%)
• Gaps: 89/426 - (20%)

Human    17 KVAALTAGTLLLLTAIGAASWAIVAVLLRSDQE--PLYPVQVSSADARLMVFDKT--------EG 71
            |.:|..:.|||||..:   :|..:..:....|:  |:|.|.:....|.|.....:        |.
  Fly     3 KQSASASATLLLLIWL---TWQTMQCIALDWQQVKPMYLVSMYPGPAGLSTSSSSPFSSSGSLEH 64

Human    72 TWRLLCSSRSNARVAGLSC-EEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVI 135
            ...:..|:..|..:.||.. .||..|     ||.|.|..        ..::....|..:::|
  Fly    65 DAEMSASNVDNRHIKGLGMGREMSAL-----SEEDDREP--------LVLNLETTPLMEKML--- 113

Human   136 SVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL---RYDGAHLCGGSLLSGDW 197
                 |.|             .:.:|||.||...:...:|:||.:   |..|.:.|||||:|...
  Fly   114 -----PEG-------------AMAMDRIFGGDVGNPHCFPYQVGMLLQRPKGLYWCGGSLISDKH 160

Human   198 VLTAAHCFPERNRVLSRWRVFAGA--VAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIAL 260
            |:|||||.....|.|    ||.||  :..|...|   .|:.:|....:..:...|.:...:|||:
  Fly   161 VITAAHCVDMAKRAL----VFLGANEIKNAKEKG---QVRLMVPSENFQIYPTWNPKRLKDDIAI 218

Human   261 VHLSSPLPLTEYIQPVCLPAAGQAL--VDGKICTVTGWGNTQY-YGQQA--GVLQEARVPIISND 320
            |.|...:...|.|.|:.||......  ...|:...:|||  :| .|..|  .||:..::.||...
  Fly   219 VRLPHAVSFNERIHPIQLPKRHYEYRSFKNKLAIASGWG--RYATGVHAISNVLRYVQLQIIDGR 281

Human   321 VCNG---ADFYGNQIKPKMFCAGYPEGGIDA---CQGDSGGPFVCEDSISRTPRWRLCGIVSWGT 379
            .|..   ..:.|..|     |.    .|.:|   |.||||||.|.:...|:  :..|.||.|:|:
  Fly   282 TCKSNFPLSYRGTNI-----CT----SGRNARSTCNGDSGGPLVLQRRHSK--KRVLVGITSFGS 335

Human   380 --GCALAQKPGVYTKVSDFREWIFQ--AIKTHSEAS 411
              ||.... |..:|||:.:.:||..  .:..|.:.:
  Fly   336 IYGCDRGY-PAAFTKVASYLDWISDETGVSAHQDTT 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	20/116 (17%)
		Tryp_SPc	163..400	CDD:238113	78/254 (31%)
CG6592	NP_648016.1	Tryp_SPc	123..359	CDD:238113	80/256 (31%)