Protein Alignment HPN and Jon65Aiii

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_648013.1
• Gene: Jon65Aiii / 38683
• FlyBaseID: FBgn0035665
• Length: 274
• Species: Drosophila melanogaster
• Alignment Length: 272
• Identity: 83/272 - (30%)
• Similarity: 122/272 - (44%)
• Gaps: 42/272 - (15%)

Human   156 RKLPV-----DRIVGGRDTSLGRWPWQVSLRY---DGAHLCGGSLLSGDWVLTAAHCFPERNRVL 212
            |.||.     .||..|:..:.|::|:||.|.:   .|:..||||::...||||||||....:.|
  Fly    28 RDLPAVTNIEGRITNGKTATSGQFPYQVGLSFASTSGSWWCGGSIIDNTWVLTAAHCTSGASAV- 91

Human   213 SRWRVFAGAVAQASPHGLQ-LGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPV 276
               .::.||..:.|...:| :.....|.|..|      ||....|||:|:. :..:..|..|..|
  Fly    92 ---TIYYGATVRTSAQLVQTVSADNFVQHASY------NSIVLRNDISLIK-TPTVAFTALINKV 146

Human   277 CLPA-AG-QALVDGKICTVTGWGNTQYYGQQ-AGVLQEARVPIISNDVCNGADFYGNQIKP-KMF 337
            .||| || .:...|:....:|||.|...... |..||.....::|...|...  ||:.:.. .:.
  Fly   147 ELPAIAGTYSTYTGQQAIASGWGKTSDSATSVANTLQYEVFEVVSVSQCQNT--YGSLVATNNVI 209

Human   338 CAGYPEGGIDACQGDSGGPFV-CEDSISRTPRWRLCGIVSW--GTGCALAQKPGVYTKVSDFREW 399
            |...| ..:..|.||||||.| ..||       :|.|:.|:  ..||. :..|..:|:|:.:.:|
  Fly   210 CVATP-NKVSTCNGDSGGPLVLVSDS-------KLIGVTSFVSSAGCE-SGAPAGFTRVTSYLDW 265

Human   400 IFQAIKTHSEAS 411
                |||::..|
  Fly   266 ----IKTNTGVS 273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	1/2 (50%)
		Tryp_SPc	163..400	CDD:238113	74/247 (30%)
Jon65Aiii	NP_648013.1	Tryp_SPc	39..266	CDD:214473	76/252 (30%)