Protein Alignment HPN and tpr

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_611611.1
• Gene: tpr / 37486
• FlyBaseID: FBgn0034661
• Length: 372
• Species: Drosophila melanogaster
• Alignment Length: 265
• Identity: 99/265 - (37%)
• Similarity: 136/265 - (51%)
• Gaps: 37/265 - (13%)

Human   150 CQD--CGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHC-------- 204
            |.|  ||...:. .|||||::|.:.::||...|.|.|...|..|||:..::|||:||
  Fly   113 CSDCVCGIANIQ-KRIVGGQETEVHQYPWVAMLLYGGRFYCAASLLNDQFLLTASHCVYGFRKER 176

Human   205 ----FPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSS 265
                ..|.:|.:|..:.....||:            |:.|..|      |:....||||::.|..
  Fly   177 ISVRLLEHDRKMSHMQKIDRKVAE------------VITHPKY------NARNYDNDIAIIKLDE 223

Human   266 PLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGN 330
            |:...|.:.|||:|..|::. .|:...|||||..:..|..:..|||.:|||:|.|.|..:. |||
  Fly   224 PVEFNEVLHPVCMPTPGRSF-KGENGIVTGWGALKVGGPTSDTLQEVQVPILSQDECRKSR-YGN 286

Human   331 QIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSD 395
            :|...|.|.||.|||.|:||||||||.  ....|.|...::.|:||||.|||.|..||||.:|:.
  Fly   287 KITDNMLCGGYDEGGKDSCQGDSGGPL--HIVASGTREHQIAGVVSWGEGCAKAGYPGVYARVNR 349

Human   396 FREWI 400
            :..||
  Fly   350 YGTWI 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	4/10 (40%)
		Tryp_SPc	163..400	CDD:238113	92/248 (37%)
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	94/250 (38%)