Protein Alignment HPN and CG11192

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_611479.2
• Gene: CG11192 / 37309
• FlyBaseID: FBgn0034507
• Length: 279
• Species: Drosophila melanogaster
• Alignment Length: 278
• Identity: 105/278 - (37%)
• Similarity: 145/278 - (52%)
• Gaps: 49/278 - (17%)

Human   145 FLAAICQDCGRRKLPVD-RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPER 208
            :|.|:....|....|.| |||||...::..:|:|||::..|.|:|||:::..|.||||||||.:
  Fly     9 WLMALVAYAGATPTPGDGRIVGGEVATIQEFPYQVSVQLQGRHICGGAIIGIDTVLTAAHCFED- 72

Human   209 NRVLSRW-----RVFAGAVAQASPH---GLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSS 265
                 .|     .|..|    :|.|   |..|.::.|:.||.|      |.:.:.||:||:.|:.
  Fly    73 -----PWSSADYTVRVG----SSEHESGGHVLSLRRVIAHGDY------NPQSHDNDLALLILNG 122

Human   266 PLPLTEYIQPVCLPA-AGQALVDGKICTVTGWG---NTQYYGQQAGVLQEAR---VPIISNDVCN 323
            .|..||::|||.|.| |.....|.:: .|:|||   .......:.||..:.|   |.::.::.|.
  Fly   123 QLNFTEHLQPVPLAALADPPTADTRL-QVSGWGFQAEESAVSGEVGVSPQLRFVDVDLVESNQCR 186

Human   324 GADFYGNQIKP---KMFCAGYPEGGIDACQGDSGGPFV---CEDSISRTPRWRLCGIVSWGTGCA 382
            .|  | :|:.|   :|.||..|  |.|:||||||||.|   .|:..:     ||.||||||.|||
  Fly   187 RA--Y-SQVLPITRRMICAARP--GRDSCQGDSGGPLVGYAAEEGPA-----RLYGIVSWGLGCA 241

Human   383 LAQKPGVYTKVSDFREWI 400
            ....|||||.|:.||.||
  Fly   242 NPNFPGVYTNVAAFRSWI 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	3/13 (23%)
		Tryp_SPc	163..400	CDD:238113	97/257 (38%)
CG11192	NP_611479.2	Tryp_SPc	27..259	CDD:214473	98/258 (38%)