Protein Alignment HPN and CG4927

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_001033953.1
• Gene: CG4927 / 36852
• FlyBaseID: FBgn0034139
• Length: 362
• Species: Drosophila melanogaster
• Alignment Length: 287
• Identity: 81/287 - (28%)
• Similarity: 114/287 - (39%)
• Gaps: 44/287 - (15%)

Human   139 DCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHL------CGGSLLSGDW 197
            :|.|...:...|     |..|.  ||||...:...:|:...|...|.:.      ||..::...:
  Fly    88 ECRRFNEIRTSC-----RTTPF--IVGGAKAAGREFPFMALLGQRGKNSSQIDWDCGAIIIHPKF 145

Human   198 VLTAAHCFP---------ERNRVLSRWRVFAG------AVAQASPHGLQLGVQAVVYHGGYLPFR 247
            |||||||..         :.|....::.|..|      ....|.|...:  |...|.|..|  ..
  Fly   146 VLTAAHCLETSETKEQRLDPNYDGPKYVVRLGELDYNSTTDDAQPQDFR--VLNYVVHPAY--GE 206

Human   248 DPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAG---QALVDGKICTVTGWGNTQYYGQQAGVL 309
            |.::....||||:|.|......:||:.|.|||..|   |..|     ...|||.|...|..:..|
  Fly   207 DDDTGSRKNDIAVVELEMEATFSEYVAPACLPLDGGNEQLQV-----AAAGWGATSESGHASSHL 266

Human   310 QEARVPIISNDVCNGADFYGNQIKPK-MFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCG 373
              .:|.:...||...:....::|..: ..|||......|.|.||||||...:..|....: ::.|
  Fly   267 --LKVSLDRYDVAECSQRLEHKIDVRTQLCAGSRSTSADTCYGDSGGPVFVQHPIYSCLK-QVIG 328

Human   374 IVSWGTGCALAQKPGVYTKVSDFREWI 400
            |.|:|..|.:...|.|||||..:.:||
  Fly   329 ITSYGLVCGVQGLPSVYTKVHLYTDWI 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	4/19 (21%)
		Tryp_SPc	163..400	CDD:238113	74/261 (28%)
CG4927	NP_001033953.1	Tryp_SPc	105..358	CDD:238113	76/263 (29%)