DRSC/TRiP Functional Genomics Resources

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Protein Alignment HPN and Ser8

DIOPT Version :10

Sequence 1:NP_002142.1 Gene:HPN / 3249 HGNCID:5155 Length:417 Species:Homo sapiens
Sequence 2:NP_610874.1 Gene:Ser8 / 36489 FlyBaseID:FBgn0019928 Length:260 Species:Drosophila melanogaster


Alignment Length:246 Identity:90/246 - (36%)
Similarity:130/246 - (52%) Gaps:21/246 - (8%)


- Green bases have known domain annotations that are detailed below.


Human   162 RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQAS 226
            |||||..:|:...||||||:..|:|.||||::|.:.::|||||. :....:|..|:.||: .:.:
  Fly    34 RIVGGTASSIEDRPWQVSLQRSGSHFCGGSIISNNIIVTAAHCL-DTPTTVSNLRIRAGS-NKRT 96

Human   227 PHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKIC 291
            ..|:.:.|.|:..|..|      ||....|||.:|.|.:.|.....|:.:.:.:|..|  .|...
  Fly    97 YGGVLVEVAAIKAHEAY------NSNSKINDIGVVRLKTKLTFGSTIKAITMASATPA--HGSAA 153

Human   292 TVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADF-YGNQIKPKMFCAGYPEGGIDACQGDSGG 355
            :::|||.|...|..:..|......|:....|..:.: ||:.||..|.||.....  |||||||||
  Fly   154 SISGWGKTSTDGPSSATLLFVDTRIVGRSQCGSSTYGYGSFIKATMICAAATNK--DACQGDSGG 216

Human   356 PFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKT 406
            |.|...        :|.|:||||..||:|..||||..:::.|:|:.||.||
  Fly   217 PLVSGG--------QLVGVVSWGRDCAVANYPGVYANIAELRDWVLQAQKT 259

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HPNNP_002142.1 Hepsin-SRCR 51..159 CDD:462736
Tryp_SPc 163..400 CDD:238113 84/237 (35%)
Ser8NP_610874.1 Tryp_SPc 35..253 CDD:238113 84/237 (35%)
Blue background indicates that the domain is not in the aligned region.

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