Protein Alignment HPN and kappaTry

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_610674.5
• Gene: kappaTry / 36215
• FlyBaseID: FBgn0043471
• Length: 263
• Species: Drosophila melanogaster
• Alignment Length: 288
• Identity: 91/288 - (31%)
• Similarity: 135/288 - (46%)
• Gaps: 62/288 - (21%)

Human   134 VISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRY------DGAHLCGGSL 192
            |||:...|.|                  ||:.|....:.|.|:.|||||      ...|.|.|.:
  Fly    15 VISISGQPEG------------------RIINGTTVDIARHPYLVSLRYRRDNESSYMHECAGVI 61

Human   193 LSGDWVLTAAHC---FPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEEN 254
            :|...::|:|.|   .||..::::    .|||..:....|....|....:|..|    ||.:.:
  Fly    62 ISEQALITSAQCLYGLPEETKLVA----VAGANTRNGTDGFIYPVANWTHHPNY----DPVTVD- 117

Human   255 SNDIALVHLSSPLPLTEY------IQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEAR 313
             |||.::.|.:.|.||..      |:|. .||.      |::.||.|||..:.:|..:..|::..
  Fly   118 -NDIGVLLLDTTLDLTLLGISSIGIRPE-RPAV------GRLATVAGWGYREEWGPSSYKLEQTE 174

Human   314 VPIISNDVCNGADFYG-NQIKPKMFCAGY-PEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVS 376
            ||::|::.|  ...|| .::..:|.|||: .:||.||||||:|||.|.:.        :|.|:||
  Fly   175 VPVVSSEQC--TQIYGAGEVTERMICAGFVVQGGSDACQGDTGGPLVIDG--------QLVGLVS 229

Human   377 WGTGCALAQKPGVYTKVSDFREWIFQAI 404
            ||.|||....|.||..|:.|.:||.:.|
  Fly   230 WGRGCARPNYPTVYCYVASFVDWIEETI 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	5/24 (21%)
		Tryp_SPc	163..400	CDD:238113	82/253 (32%)
kappaTry	NP_610674.5	Tryp_SPc	26..256	CDD:238113	84/256 (33%)