Protein Alignment HPN and CG1773

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_610512.1
• Gene: CG1773 / 35999
• FlyBaseID: FBgn0033439
• Length: 317
• Species: Drosophila melanogaster
• Alignment Length: 299
• Identity: 87/299 - (29%)
• Similarity: 123/299 - (41%)
• Gaps: 66/299 - (22%)

Human   151 QDCG--RRKLPVD----RIVGGRDTSLGRWPWQVSLRYDG---AHLCGGSLLSGDWVLTAAHCFP 206
            ||||  ...:|..    ||.|||.:||...||...|...|   ...|||||||..:||||||||.
  Fly    44 QDCGVLSNLIPAQRLRRRITGGRKSSLLSQPWMAFLHISGDIEMCRCGGSLLSELFVLTAAHCFK 108

Human   207 --ERNRVLSRW------------------RVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNS 251
              .|::.:..|                  ||.|..|.:.:.....|..:..:::.||
  Fly   109 MCPRSKEIRVWLGELDISSTSDCVTYNYQRVCALPVEEFTIDKWILHEEFNLFYPGY-------- 165

Human   252 EENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVD----GKICTVTGWGNTQYYGQQAGVLQEA 312
                 ||||:.|:..:...::|:|:|||...:.|..    |:.....|||.|: ..:.|....|.
  Fly   166 -----DIALIKLNKKVVFKDHIRPICLPLTDELLAFTLQLGQSYMAVGWGRTE-SRRFANSTMEV 224

Human   313 RVPIISNDVC-NGADFYGNQIKPKMFCAG--YPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGI 374
            .   |:.:.| :|.|       ....||.  |    :|.|.||||||.:.:.::....|....|:
  Fly   225 H---INTEKCTDGRD-------TSFLCANGDY----VDTCTGDSGGPLIWKTTLFGKARTVQFGV 275

Human   375 VSWGT-GCALAQKPGVYTKVSDFREWIFQAIKTHSEASG 412
            ||.|: .|...|| ..|..|..:..||...:...|:..|
  Fly   276 VSTGSQNCGAGQK-AYYMDVPTYVPWILAKMAELSDFKG 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	4/9 (44%)
		Tryp_SPc	163..400	CDD:238113	77/267 (29%)
CG1773	NP_610512.1	Tryp_SPc	61..301	CDD:214473	78/268 (29%)