Protein Alignment HPN and CG8172

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_001097235.2
• Gene: CG8172 / 35905
• FlyBaseID: FBgn0033362
• Length: 561
• Species: Drosophila melanogaster
• Alignment Length: 262
• Identity: 103/262 - (39%)
• Similarity: 131/262 - (50%)
• Gaps: 29/262 - (11%)

Human   153 CGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDG----AHLCGGSLLSGDWVLTAAHCF---PERNR 210
            ||......:|||||..|..|..||||:|...|    ...|||:|:|..||:|||||.   |..|.
  Fly   306 CGEVYTRSNRIVGGHSTGFGSHPWQVALIKSGFLTRKLSCGGALISNRWVITAAHCVASTPNSNM 370

Human   211 V--LSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYI 273
            .  |..|.| .|...:.:..  :.|::....|..|      |..:..||:||:.|...:...::|
  Fly   371 KIRLGEWDV-RGQEERLNHE--EYGIERKEVHPHY------NPADFVNDVALIRLDRNVVYKQHI 426

Human   274 QPVCLPAAGQALVDGKICTVTGWGNTQYYGQQA--GVLQEARVPIISNDVCN---GADFYGNQIK 333
            .|||||.:...|. ||:.||.|||.|: :||..  .||||..|.:||||.|.   .|......|.
  Fly   427 IPVCLPPSTTKLT-GKMATVAGWGRTR-HGQSTVPSVLQEVDVEVISNDRCQRWFRAAGRREAIH 489

Human   334 PKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFRE 398
            ....||||.:||.|:||||||||.    :::...|..|.|:||||.||.....|||||.:..|..
  Fly   490 DVFLCAGYKDGGRDSCQGDSGGPL----TLTMDGRKTLIGLVSWGIGCGREHLPGVYTNIQRFVP 550

Human   399 WI 400
            ||
  Fly   551 WI 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	2/5 (40%)
		Tryp_SPc	163..400	CDD:238113	98/250 (39%)
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113	100/252 (40%)