Protein Alignment HPN and Jon44E

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_724699.1
• Gene: Jon44E / 35853
• FlyBaseID: FBgn0001285
• Length: 271
• Species: Drosophila melanogaster
• Alignment Length: 268
• Identity: 83/268 - (30%)
• Similarity: 121/268 - (45%)
• Gaps: 51/268 - (19%)

Human   156 RKLPV----------DRIVGGRDTSLGRWPWQVSLRY-DGAHLCGGSLLSGDWVLTAAHCFPERN 209
            |.:||          .||..|.....|:.|:.|.|.: ||.:.||||::...||||||||....|
  Fly    24 RAVPVKDMPRAGKIEGRITNGYPAYEGKIPYIVGLSFNDGGYWCGGSIIDHTWVLTAAHCTNSAN 88

Human   210 RVLSRWRVFAGAVAQASPHGLQ----LGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLT 270
            .||    ::.||   :..|..|    :....::.|..:..|.       :|||||:.    :|..
  Fly    89 HVL----IYFGA---SFRHEAQYTHWVSRSDMIQHPDWNDFL-------NNDIALIR----IPHV 135

Human   271 EY---IQPVCLPAAGQAL--VDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYG- 329
            ::   :..|.||:.....  ..|.....:|||.|......:..|....|.||.|:.|.  ::||
  Fly   136 DFWSLVNKVELPSYNDRYNSYSGWWAVASGWGLTDNNSGMSNYLNCVDVQIIDNNDCR--NYYGS 198

Human   330 NQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGT--GCALAQKPGVYTK 392
            |.|.....|.. .:||..:|.||||||.|..|:.      |:.||||:|:  ||. |.:|..:|:
  Fly   199 NYITDNTICIN-TDGGKSSCSGDSGGPLVLHDNN------RIVGIVSFGSGEGCT-AGRPAGFTR 255

Human   393 VSDFREWI 400
            |:.:.:||
  Fly   256 VTGYLDWI 263

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	1/2 (50%)
		Tryp_SPc	163..400	CDD:238113	77/249 (31%)
Jon44E	NP_724699.1	Tryp_SPc	41..266	CDD:238113	79/251 (31%)