Protein Alignment HPN and l(2)k05911

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_723797.3
• Gene: l(2)k05911 / 34731
• FlyBaseID: FBgn0284244
• Length: 639
• Species: Drosophila melanogaster
• Alignment Length: 276
• Identity: 105/276 - (38%)
• Similarity: 136/276 - (49%)
• Gaps: 46/276 - (16%)

Human   153 CGRRKLPV----DRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLS 213
            || .|.||    :|||||.:.|...:||...|...|...|||||::...:||||||...    ::
  Fly   387 CG-NKNPVTPDQERIVGGINASPHEFPWIAVLFKSGKQFCGGSLITNSHILTAAHCVAR----MT 446

Human   214 RWRVFAGAVAQASPH--GLQLGVQAV-------VYHGGYLPFRDPNSEENS---NDIALVHLSSP 266
            .|.| |...|....:  |....||.|       |.|.|:         |.|   ||:|::.||.|
  Fly   447 SWDV-AALTAHLGDYNIGTDFEVQHVSRRIKRLVRHKGF---------EFSTLHNDVAILTLSEP 501

Human   267 LPLTEYIQPVCLPAA---GQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFY 328
            :|.|..|||:|||.:   ......|::.||.|||:.:..|.|..:||:..:||.:|..|  |..|
  Fly   502 VPFTREIQPICLPTSPSQQSRSYSGQVATVAGWGSLRENGPQPSILQKVDIPIWTNAEC--ARKY 564

Human   329 GNQ----IKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGV 389
            |..    |...|.|||  :...|:|.||||||.|..|.    .|:...||||||.||...|.|||
  Fly   565 GRAAPGGIIESMICAG--QAAKDSCSGDSGGPMVINDG----GRYTQVGIVSWGIGCGKGQYPGV 623

Human   390 YTKVSDFREWIFQAIK 405
            ||:|:....||::.||
  Fly   624 YTRVTSLLPWIYKNIK 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	3/5 (60%)
		Tryp_SPc	163..400	CDD:238113	95/255 (37%)
l(2)k05911	NP_723797.3	CLIP	111..174	CDD:197829
		PTZ00449	<198..>376	CDD:185628
		Tryp_SPc	400..637	CDD:238113	97/258 (38%)