Protein Alignment HPN and Phae2

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_609551.2
• Gene: Phae2 / 34638
• FlyBaseID: FBgn0263235
• Length: 265
• Species: Drosophila melanogaster
• Alignment Length: 269
• Identity: 90/269 - (33%)
• Similarity: 126/269 - (46%)
• Gaps: 35/269 - (13%)

Human   146 LAAICQDCG---RRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPE 207
            |.|:|...|   ....|..|:|||:..:....|:.||::|.|.|.|..::::.:|::|||||...
  Fly    12 LLAVCVSQGSGLALDQPEGRVVGGKAAAANSAPYIVSMQYGGTHYCAANIINSNWLVTAAHCLAN 76

Human   208 RNRVLSRWRVFAGAVAQASPHGLQLGVQAV------VYHGGYLPFRDPNSEENSNDIALVHLSSP 266
            ||:||....| ||::|.|.........|..      :|.||.:|:          ||.|::..:.
  Fly    77 RNQVLGSTLV-AGSIAVAGTASTTQKRQITHYVINDLYTGGTVPY----------DIGLIYTPTA 130

Human   267 LPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQA--GVLQEAR-VPIISNDVCNGA-DF 327
            ...|..:.||.||::| ....|| ..:.|||:|......:  ..||||: :||||.|.|..| ..
  Fly   131 FTWTAAVAPVKLPSSG-VRPTGK-ADLFGWGSTSKTNSPSYPKTLQEAKNIPIISLDSCAAALGS 193

Human   328 YGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWG-TGCALAQKPGVYT 391
            .|..:.....|.|...||...|..|||||.| :.::       |.|||||| ..|.....|.||.
  Fly   194 KGQDVHTTNLCTGPLTGGTSFCTSDSGGPLV-QGNV-------LIGIVSWGKLPCGQPNSPSVYV 250

Human   392 KVSDFREWI 400
            :||.|..||
  Fly   251 QVSSFITWI 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	4/15 (27%)
		Tryp_SPc	163..400	CDD:238113	82/247 (33%)
Phae2	NP_609551.2	Tryp_SPc	32..262	CDD:238113	84/249 (34%)