Protein Alignment HPN and CG11912

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_608517.1
• Gene: CG11912 / 33205
• FlyBaseID: FBgn0031248
• Length: 271
• Species: Drosophila melanogaster
• Alignment Length: 271
• Identity: 84/271 - (30%)
• Similarity: 113/271 - (41%)
• Gaps: 61/271 - (22%)

Human   159 PVDRIVGGRDTSLGRWPWQVSLR-YDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAV 222
            |..||:.|.:.:.|..|:.|||: ...:|.|.||||....::|||||.     ..::.:..|||.
  Fly    26 PEGRIINGYEAAKGEAPYIVSLQTTSNSHFCAGSLLDEVTIVTAAHCL-----TYNQGQAVAGAH 85

Human   223 AQASPHGLQL----GVQAVV---YHGGYLPFRDPNSEENSNDIALVHL---------------SS 265
            ::.....:|:    ..|.|:   |.||..|          |||.|:.|               |:
  Fly    86 SRTDQENVQIRKFTNAQYVIHENYGGGVGP----------NDIGLILLKEEDAFDLNAVARDGSN 140

Human   266 PLPLTEYIQPVCLPA-AGQALVDGKICTVTGWGNTQYYGQQAGV----LQEARVPIISNDVCNGA 325
            |      :..|.||: ..|...||.:   .|||.     ..:|:    ||:....|:..:.|..|
  Fly   141 P------VSAVSLPSKTFQGTSDGYL---YGWGR-----DNSGLLPLNLQKLDAIIVDYNECKAA 191

Human   326 DFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWG-TGCALAQKPGV 389
            ....|.:.....|...|.....:|.||||||.|.:.| ||..  .|.|||||| |.|.....|.|
  Fly   192 LPSNNSLAETNVCTHTPGKADGSCNGDSGGPLVSQSS-SRGA--ELIGIVSWGYTPCLSTTYPSV 253

Human   390 YTKVSDFREWI 400
            ||.||.|..||
  Fly   254 YTSVSSFLPWI 264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	84/271 (31%)
		Tryp_SPc	163..400	CDD:238113	80/265 (30%)
CG11912	NP_608517.1	Tryp_SPc	29..264	CDD:214473	81/266 (30%)