Protein Alignment HPN and CG14227

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_608345.2
• Gene: CG14227 / 32978
• FlyBaseID: FBgn0031058
• Length: 286
• Species: Drosophila melanogaster
• Alignment Length: 283
• Identity: 72/283 - (25%)
• Similarity: 117/283 - (41%)
• Gaps: 61/283 - (21%)

Human   152 DCGRRKLPVDRIVGGRDTSLGRW------------PWQVSLRYDGAHLCGGSLLSGDWVLTAAHC 204
            :|| |.||.       :..|..|            ||.||:..:|...|.|||::..:|||||||
  Fly    30 ECG-RSLPT-------NAKLTWWNYFDSSTDIQANPWIVSVIVNGKAKCSGSLINHRFVLTAAHC 86

Human   205 -FPERNRV----LSRWRVFAGAVAQASPHGLQLG------VQAVVYHGGYLPFRDPNSEENSNDI 258
             |.|..:|    ...|.     ..|....|.:|.      :...:.|.|:     ...:....||
  Fly    87 VFREAMQVHLGDFDAWN-----PGQNCSSGARLSNAYCVRIDKKIVHAGF-----GKIQAQQYDI 141

Human   259 ALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTV-----TGWGNT-QYYGQQAGVLQEARVPII 317
            .|:.:...:..:::::|:||      |::..:..:     |.||.| :.:.....||:.:....|
  Fly   142 GLLRMQHAVQYSDFVRPICL------LINEPVAAIDRFQLTVWGTTAEDFRSIPRVLKHSVGDRI 200

Human   318 SNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWG-TGC 381
            ..::|...  :..|:.....|. :.|.. .||:|||||||..:.....|.|....||:.:| :.|
  Fly   201 DRELCTLK--FQQQVDESQICV-HTETS-HACKGDSGGPFSAKILYGGTYRTFQFGIIIFGLSSC 261

Human   382 ALAQKPGVYTKVSDFREWIFQAI 404
            |   ...|.|.|:.:.:||:.|:
  Fly   262 A---GLSVCTNVTFYMDWIWDAL 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	3/6 (50%)
		Tryp_SPc	163..400	CDD:238113	64/266 (24%)
CG14227	NP_608345.2	Tryp_SPc	57..277	CDD:214473	62/242 (26%)