Protein Alignment HPN and Hayan

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_001097020.1
• Gene: Hayan / 32831
• FlyBaseID: FBgn0030925
• Length: 637
• Species: Drosophila melanogaster
• Alignment Length: 298
• Identity: 85/298 - (28%)
• Similarity: 126/298 - (42%)
• Gaps: 52/298 - (17%)

Human   125 LPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYD----GA 185
            ||..:|    .||..|.:.|        .|.:.|.| .|:.|.....|.:|...::.|:    .|
  Fly   360 LPEKER----PSVAACEKIR--------SGGKPLTV-HILDGERVDRGVYPHMAAIAYNSFGSAA 411

Human   186 HLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPN 250
            ..|||||::..:|||||||....:...|..|:.|..:....|....:.|..|..|..|      :
  Fly   412 FRCGGSLIASRFVLTAAHCVNSDDSTPSFVRLGALNIENPEPGYQDINVIDVQIHPDY------S 470

Human   251 SEENSNDIALVHLSSPLPLTEYIQPVCL------PAAGQALVDGKICTVTGWGNTQYYGQQAG-V 308
            ......|||::.|:.....::.|:|.||      |.|.....      |.|||......:... :
  Fly   471 GSSKYYDIAILQLAEDAKESDVIRPACLYTDRSDPPANYKYF------VAGWGVMNVTNRAVSKI 529

Human   309 LQEARVPIISNDVCNGADFYGNQ----------IKPKMFCAGYPEGGIDACQGDSGGPFVCE-DS 362
            |..|.:.::..|.||.:  :..|          :.....||.......||||||||||.:.| |.
  Fly   530 LLRAALDLVPADECNAS--FAEQPSANRTLRRGVIASQLCAADKNQRKDACQGDSGGPLILEIDD 592

Human   363 ISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWI 400
            :..|  :.:.|::|.|.||| .:.||:||:||.|.::|
  Fly   593 VDGT--YSIVGVISSGFGCA-TKTPGLYTRVSSFLDYI 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	8/33 (24%)
		Tryp_SPc	163..400	CDD:238113	74/258 (29%)
Hayan	NP_001097020.1	CLIP	32..80	CDD:197829
		Tryp_SPc	385..630	CDD:238113	75/260 (29%)