Protein Alignment HPN and CG4653

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_573150.2
• Gene: CG4653 / 32650
• FlyBaseID: FBgn0030776
• Length: 254
• Species: Drosophila melanogaster
• Alignment Length: 289
• Identity: 77/289 - (26%)
• Similarity: 126/289 - (43%)
• Gaps: 63/289 - (21%)

Human   127 HTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGS 191
            |::.||.|:.|        ...:.|.   .:||.:         :|..|..:|||.:|.|:|||:
  Fly     9 HSRLLLLVVIV--------TLGVVQS---SRLPAE---------VGSQPHSISLRRNGVHVCGGA 53

Human   192 LLSGDWVLTAAHC---------FPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFR 247
            |:...|:||||||         :|.::     :.|..|:: |....|..:.:..::.|..|
  Fly    54 LIREKWILTAAHCVSLGGGQQSYPAKS-----YNVRVGSI-QRLTGGQLVPLSKIIIHTNY---- 108

Human   248 DPNSEENSNDIALVHLSSPLPLTEYIQPVCL----PAAGQALVDGKICTVTGWGNTQYYGQQAGV 308
            ..:....|||:||:.|.:.:.|.....|:.|    ||||..::      .:|||::|..|..:.|
  Fly   109 SSSDAVGSNDLALLELETSVVLNANTNPIDLATERPAAGSQII------FSGWGSSQVDGSLSHV 167

Human   309 LQEARVPIISNDVCNGADFYGNQIKPKMFC-AGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLC 372
            ||.|....:|...|. .:.|..|  ..:.| :...|.....|.||:|.|....:        :|.
  Fly   168 LQVATRQSLSASDCQ-TELYLQQ--EDLLCLSPVDEDFAGLCSGDAGAPASYNN--------QLV 221

Human   373 GIVS-WGTGCALAQKPGVYTKVSDFREWI 400
            ||.: :.:||. :::|..|..|:...|||
  Fly   222 GIAAFFVSGCG-SEQPDGYVDVTQHLEWI 249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	6/31 (19%)
		Tryp_SPc	163..400	CDD:238113	67/251 (27%)
CG4653	NP_573150.2	Tryp_SPc	30..252	CDD:238113	70/257 (27%)