Protein Alignment HPN and CG31220

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_732440.2
• Gene: CG31220 / 326126
• FlyBaseID: FBgn0051220
• Length: 363
• Species: Drosophila melanogaster
• Alignment Length: 293
• Identity: 87/293 - (29%)
• Similarity: 133/293 - (45%)
• Gaps: 40/293 - (13%)

Human   135 ISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHL----------CG 189
            |.:| ||:.........|||:.: ..:|::||.:.:|..:||...|.|.....          ||
  Fly    78 IYIC-CPKPANTLPSYPDCGKPQ-TTNRVIGGTEPNLNEYPWLAMLLYRNRSAFNPDRELVPSCG 140

Human   190 GSLLSGDWVLTAAHCFPERNRVLSRWR------------VFAGAVAQASPHGLQLGVQAVVYHGG 242
            |||::..:|||||||..:....:.|.|            :..||....:|..|.:.|:::..|..
  Fly   141 GSLINTRYVLTAAHCVTDTVLQIQRVRLGEHTTSHNPDCISRGARIVCAPTHLDIDVESITSHND 205

Human   243 YLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAG 307
            |    ||.:....||||||.|..|:..|....|:|:....::|:..|: .|.|||.|..:...:.
  Fly   206 Y----DPANYTFRNDIALVRLKEPVRYTMAYYPICVLDYPRSLMKFKM-YVAGWGKTGMFDTGSK 265

Human   308 VLQEARVPIISNDVCNGADFYGNQ-IKPK-MFCAGYPEGGID---ACQGDSGGPFVCEDSISRTP 367
            ||:.|.|.:...:.|  ::.|.:: ..|: ..||    ||:|   .|.||||.|.:.....|...
  Fly   266 VLKHAAVKVRKPEEC--SEKYAHRHFGPRFQICA----GGLDNRGTCDGDSGSPLMGTSGRSYET 324

Human   368 RWRLCGIVSWGTGCALAQKPGVYTKVSDFREWI 400
            ...|.||.|:|..|.....|.|:|:.:.|.:||
  Fly   325 ITFLAGITSYGGPCGTIGWPSVFTRTAKFYKWI 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	7/23 (30%)
		Tryp_SPc	163..400	CDD:238113	77/263 (29%)
CG31220	NP_732440.2	Tryp_SPc	104..360	CDD:238113	79/265 (30%)