Protein Alignment HPN and CG8952

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_573072.1
• Gene: CG8952 / 32525
• FlyBaseID: FBgn0030688
• Length: 276
• Species: Drosophila melanogaster
• Alignment Length: 286
• Identity: 91/286 - (31%)
• Similarity: 134/286 - (46%)
• Gaps: 36/286 - (12%)

Human   131 LLEVISVCDCPRGRFLAAICQDCGRRKLPVD-RIVGGRDTSLGRWPWQVSLRYDGAH--LCGGSL 192
            ||..|||...|        ........:.:| |||.|.|..||::||||.|:.|...  |||||:
  Fly    13 LLAAISVVGQP--------FDPANSSPIKIDNRIVSGSDAKLGQFPWQVILKRDAWDDLLCGGSI 69

Human   193 LSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSND 257
            :|..||||||||   .|.:.|.:.:| |.|...:.:.|.:....::.|..|       :::.:||
  Fly    70 ISDTWVLTAAHC---TNGLSSIFLMF-GTVDLFNANALNMTSNNIIIHPDY-------NDKLNND 123

Human   258 IALVHLSSPLPLTEYIQPVCLPAAGQALVD--GKICTVTGWGNTQ-YYGQQAGVLQEARVPIISN 319
            ::|:.|..||..:..||.:.|.......:|  |.:.|:.|:|.|: .|...:..|..|:|.||.|
  Fly   124 VSLIQLPEPLTFSANIQAIQLVGQYGDSIDYVGSVATIAGFGYTEDEYLDYSETLLYAQVEIIDN 188

Human   320 DVCNGADFYGNQ-IKPKMFCA-GYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSW--GTG 380
            ..|  ...||.. :.....|| |:....:..|.||||||.:..:...:  :|:..||.|:  ...
  Fly   189 ADC--VAIYGKYVVVDSTMCAKGFDGSDMSTCTGDSGGPLILYNKTIQ--QWQQIGINSFVAEDQ 249

Human   381 CALAQKPGVYTKVSDFREWIFQAIKT 406
            |.. :.|..|.:||.|..:|  |.||
  Fly   250 CTY-RLPSGYARVSSFLGFI--ADKT 272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	6/27 (22%)
		Tryp_SPc	163..400	CDD:238113	79/245 (32%)
CG8952	NP_573072.1	Tryp_SPc	37..268	CDD:214473	80/246 (33%)