Protein Alignment HPN and spirit

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_572492.1
• Gene: spirit / 31797
• FlyBaseID: FBgn0030051
• Length: 393
• Species: Drosophila melanogaster
• Alignment Length: 395
• Identity: 103/395 - (26%)
• Similarity: 163/395 - (41%)
• Gaps: 70/395 - (17%)

Human    26 LLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSC 90
            |||::....|..|..|:..:|.:..::||:         .||:        |.....||..| :|
  Fly    17 LLLVSLPLLAVHATPAISPQSLRGIIFPVE---------TFDE--------CQLEDVARTKG-TC 63

Human    91 EEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPR-----GRFLAAIC 150
            ..|....:..:..|:.|   .:..:.:|.    |..|        .||..|.     .|.....|
  Fly    64 RRMEDCPSALNGWLERR---ESPKTCYFV----RFDH--------YVCCAPAVAPIVTRSSQQAC 113

Human   151 QDCGR--RKLPVDR----IVGGRDTSLGRWPWQVSL----RYDGA--HLCGGSLLSGDWVLTAAH 203
            .:..:  :...:|.    :|||..|....:|:..:|    .:|..  :.|||:|::.::||||||
  Fly   114 NELNKVSKVKEIDEFFVSVVGGMPTRPREFPFMAALGWRSNFDQRIYYRCGGALIANNFVLTAAH 178

Human   204 CFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLP 268
            |........|:.|:  |........|..:.::.|:.|..|      ::....|||||:.|.:  .
  Fly   179 CADLGGEPPSQVRL--GGDNLTLTEGEDISIRRVIIHPDY------SASTAYNDIALLELET--A 233

Human   269 LTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCN---GADFYGN 330
            ....::|.|:..  |..|...:.|..|:|.|.:.|..:..|.:..:..:||:.|.   ..|....
  Fly   234 AKPELKPTCIWT--QKEVTNTLVTAIGYGQTSFAGLSSAQLLKVPLKSVSNEECQHHYQKDQLAQ 296

Human   331 QIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSD 395
            .:.....|||...|..|.||||||||.:.:|.:    ...:.||.|.|.||| :..|.|||:||.
  Fly   297 GVLGTQMCAGDITGERDTCQGDSGGPLLMQDGL----LGYVVGITSLGQGCA-SGPPSVYTRVSS 356

Human   396 FREWI 400
            |.:||
  Fly   357 FVDWI 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	20/114 (18%)
		Tryp_SPc	163..400	CDD:238113	73/245 (30%)
spirit	NP_572492.1	CLIP	51..98	CDD:197829	13/62 (21%)
		Tryp_SPc	132..364	CDD:238113	75/247 (30%)