Protein Alignment HPN and CG1632

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_572467.1
• Gene: CG1632 / 31763
• FlyBaseID: FBgn0030027
• Length: 1056
• Species: Drosophila melanogaster
• Alignment Length: 515
• Identity: 104/515 - (20%)
• Similarity: 168/515 - (32%)
• Gaps: 187/515 - (36%)

Human    39 IVAVLLRSDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSE 103
            :.|.||:  .|||.|.......|...||.: :|....||:.       ||..:....:|. |.||
  Fly   577 LAADLLQ--PEPLVPYLSRFHSAGYAVFSE-KGVVGKLCAE-------GLEGDAKLVVRQ-TVSE 630

Human   104 LDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCD------------CPRGRFLAAICQD--CG 154
            ...::.|......|...::     |:||.:.:.|.|            |||.:.|...|.:  ||
  Fly   631 SLCKSLGYESVEIFDVQND-----TERLNDYVRVLDPHAPEISFIRTHCPRRQVLYVGCGELRCG 690

Human   155 --------RRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRV 211
                    ::.|.:.::     ::.|.|||.|:|..:..|:|.|:|::.|||||...||..:.|
  Fly   691 VQSALFNAKQHLSLPKM-----SAPGDWPWLVALFREDIHVCDGTLITQDWVLTTEGCFQGQPR- 749

Human   212 LSRWRVFAGAV--AQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQ 274
             :.|....|||  :..:|...:..:..::           .|....:..|||.|.:|:..:::::
  Fly   750 -ATWMAIVGAVRLSAKAPWTQRRRIIGMI-----------KSPVEGSTAALVRLETPVSYSDHVR 802

Human   275 PVCLPAA------------------------GQAL------------------------------ 285
            |:|||.|                        ||.:
  Fly   803 PICLPDALQRRLLQQPPAQRRSHVPVAERLEGQLVSQQRSRLSQENQQFFLIPSQEQQDSSTENQ 867

Human   286 ------------------------------VDG--------------KICTVTGWGNTQYYGQQA 306
                                          :||              ...|||..........:|
  Fly   868 GDEDQDEQEDHFGGESAASYMPKAEALHQELDGYPLPDHAPQVNYYSSSSTVTSSSTAARIATKA 932

Human   307 GVLQEARVPIISNDVCNGADFYG--------NQIKPKM----------------FCAGYPEGGID 347
            .:|  |.||.....:....:..|        .:::.||                .|........|
  Fly   933 PIL--AAVPAAQEQIWTNCNTLGWSRQRDHLQRVQLKMGDMAPCENVSIATVNSMCMEATYQKYD 995

Human   348 ACQGD-SGGPFVCEDSISRTPRWRLCGIVSWGTGCAL--AQKPGVYTKVSDFREWIFQAI 404
            ..|.: ||.|..|  .|..|.:|.|.|:.||...|..  .::|.:|.|::....||.:.|
  Fly   996 CTQEEYSGAPVQC--LIPGTNQWALIGVSSWRIACGPTGVERPRMYDKIASNAAWIRETI 1053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	28/129 (22%)
		Tryp_SPc	163..400	CDD:238113	67/363 (18%)
CG1632	NP_572467.1	SEA	232..>309	CDD:460188
		CRD_FZ	384..502	CDD:143549
		PRKCSH-like	<503..>582	CDD:372423	1/4 (25%)
		LDLa	536..571	CDD:238060
		Tryp_SPc	708..>809	CDD:473915	33/113 (29%)