Protein Alignment HPN and CG33225

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_001286682.1
• Gene: CG33225 / 2768860
• FlyBaseID: FBgn0053225
• Length: 307
• Species: Drosophila melanogaster
• Alignment Length: 311
• Identity: 85/311 - (27%)
• Similarity: 133/311 - (42%)
• Gaps: 67/311 - (21%)

Human   133 EVISVCDCPRGRFLAA---ICQDCGRRKLP--VDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSL 192
            |::.:.....|..|.:   :..|||..:.|  :.|:|||.|......||.|.:..:....|.|||
  Fly    22 EIVLLASLVLGARLGSSTLLTNDCGTTRHPSRIRRVVGGNDADRFANPWMVMVLGENNVFCSGSL 86

Human   193 LSGDWVLTAAHC---FP--------ERN----------RVLSRWRVFAGAVAQASPHGLQLGVQA 236
            ::..:|||:|.|   .|        :||          :|:.        :.|...|| |.|::.
  Fly    87 ITRLFVLTSASCLLSLPKQVILGEYDRNCTSADCTSIRQVID--------IDQKIIHG-QFGLET 142

Human   237 VVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQY 301
            |                ...||||:.|:..:.:::|::|:||....|.....:..|.||||.|:
  Fly   143 V----------------KKYDIALLRLAKKVSISDYVRPICLSVDRQVGRSVQHFTATGWGTTE- 190

Human   302 YGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRT 366
            :.:.:.:||...:..|:...|.|.  ....|.....|.|.|..  |.|.||:|||......|...
  Fly   191 WNEPSTILQTVTLSKINRKYCKGR--LRQNIDASQLCVGGPRK--DTCSGDAGGPLSLTLKIDGD 251

Human   367 PRWR------LCGIVSWG-TGCALAQKPGVYTKVSDFREWIFQAI-KTHSE 409
            .:|.      |.||||:| :.|:   ..||||.|..:.:||.:.| |:::|
  Fly   252 GKWNNKSRAFLIGIVSYGSSSCS---GIGVYTNVEHYMDWIVRTINKSNTE 299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	6/28 (21%)
		Tryp_SPc	163..400	CDD:238113	72/264 (27%)
CG33225	NP_001286682.1	Tryp_SPc	56..289	CDD:214473	73/265 (28%)