Protein Alignment HPN and CG33458

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_995854.2
• Gene: CG33458 / 2768846
• FlyBaseID: FBgn0053458
• Length: 281
• Species: Drosophila melanogaster
• Alignment Length: 272
• Identity: 85/272 - (31%)
• Similarity: 124/272 - (45%)
• Gaps: 35/272 - (12%)

Human   152 DCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERN-RVLSR- 214
            |||..|... ||.||||:.|...||...|..:...:||||||:..:||||||||.::| :||.|
  Fly    28 DCGISKYTY-RITGGRDSPLMLNPWLAYLHINSKFICGGSLLNHWFVLTAAHCFRDKNAKVLVRL 91

Human   215 ------WRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYI 273
                  .::.......|:|| |:..:...:.|..|       ...:..||||..|:..:..|:.|
  Fly    92 GENDASQKIDCNESECAAPH-LEYMIMQKLIHPLY-------RTAHYYDIALAKLNRYVVYTDSI 148

Human   274 QPVC--LPAAGQALVDG-KICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPK 335
            :|:|  |....|..||. :...:||||.|. ..:.:..||..|:|.|....|.  .::|..:...
  Fly   149 RPICLMLNPNWQVYVDTIRYFIITGWGATN-ASEVSDKLQLTRIPQIDRFTCR--YWFGYMVDRT 210

Human   336 MFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKP----GVYTKVSDF 396
            ..|||..:..:.  :||||||...........|:...||||.      .::|    .|:|.:..:
  Fly   211 HICAGESKHYVG--KGDSGGPLGSMVDYKYAKRFFQFGIVSH------LRQPFHGVSVFTNILSY 267

Human   397 REWIFQAIKTHS 408
            ..||.:.|.|:|
  Fly   268 SNWIHRTIITNS 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	4/6 (67%)
		Tryp_SPc	163..400	CDD:238113	75/251 (30%)
CG33458	NP_995854.2	Tryp_SPc	38..274	CDD:238113	77/254 (30%)