Protein Alignment HPN and Erasp

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_725487.1
• Gene: Erasp / 246448
• FlyBaseID: FBgn0050090
• Length: 291
• Species: Drosophila melanogaster
• Alignment Length: 294
• Identity: 86/294 - (29%)
• Similarity: 135/294 - (45%)
• Gaps: 44/294 - (14%)

Human   137 VCDCPRGRFLAAICQDCGRRKLPVD-RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLT 200
            :|....|.:|.   ..||.....:. :|:||||..:...||...:......:|||:|::..:|||
  Fly    16 LCSLGNGEYLE---PRCGLTANTIAFKIIGGRDAIINSNPWMAYIHSSVKLICGGTLITQRFVLT 77

Human   201 AAHCFPERNRVLSRWRVFAG----------AVAQASPHGLQLGVQAVVYHGGYLPFRDPNSE-EN 254
            ||||..|.:.|..|...:..          .:.:|..|.:.:..:    ||.:       || :|
  Fly    78 AAHCVNEGSAVKVRLGEYDDTATEDCNSKICIPRAEEHDVDMAFR----HGKF-------SEIKN 131

Human   255 SNDIALVHLSSPLPLTEYIQPVC--LPAAGQALVDG-KICTVTGWGNTQYYGQQAGVLQEARVPI 316
            .|||||:.|:..:....:|.|:|  |..:.:.|||. :....||||.|:.: :..||||..::..
  Fly   132 LNDIALLRLAKFVTFKAHISPICIILGTSKRELVDSIEWFVATGWGETRTH-RTRGVLQITQLQR 195

Human   317 ISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWR--LCGIVSWGT 379
            .::..|..|  .|..::....|||  ..|.|.|.||||||..  .::....:.|  ..|:||:|:
  Fly   196 YNSSQCMQA--LGRLVQQNQICAG--RLGSDTCNGDSGGPLF--QTVRHMDKMRPVQFGVVSYGS 254

Human   380 -GCALAQKPGVYTKVSDFREWIFQAIK--THSEA 410
             .|:   ..||||.|..:.:||...::  ||..|
  Fly   255 RECS---GIGVYTDVYSYADWIATVVQQNTHVPA 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	5/21 (24%)
		Tryp_SPc	163..400	CDD:238113	76/253 (30%)
Erasp	NP_725487.1	Tryp_SPc	40..276	CDD:238113	78/256 (30%)