Protein Alignment HPN and CG30087

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_725489.2
• Gene: CG30087 / 246446
• FlyBaseID: FBgn0050087
• Length: 277
• Species: Drosophila melanogaster
• Alignment Length: 287
• Identity: 90/287 - (31%)
• Similarity: 134/287 - (46%)
• Gaps: 37/287 - (12%)

Human   134 VISVCDCPRGR-----FLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLL 193
            ||::|...:.|     ||..:|......:..: |:|.|::..:...|:.|.:..:....||||:|
  Fly     9 VIAICLIRQQRIVDAQFLNPLCGVTYESQTAM-RVVNGKEAVIRSAPFMVYVTNNSLTHCGGSIL 72

Human   194 SGDWVLTAAHC-FPERNRVLSRWRVFAGAVAQ---ASPHGLQLGVQAVVYHGGYLPFRDPNSEEN 254
            :..::|||||| ||.....|....:......|   .||...:.|:...:.|..|      |:..:
  Fly    73 NSRYILTAAHCVFPNLRLRLGEHNIRTDPDCQGSNCSPRSEEYGIMKAITHRFY------NAANH 131

Human   255 SNDIALVHLSSPLPLTEYIQPVCL---PAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPI 316
            .|||||:.|:..:....:|||:|:   ||:..::...:   ..|||.|:..| ...:||.|.:..
  Fly   132 VNDIALLKLNRSINFNVHIQPICILLNPASAPSVATYQ---TFGWGETKKNG-FPHLLQTAELRA 192

Human   317 ISNDVCN---GADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWG 378
            .....|:   .|...||||     |||:.|.  |.|.||||||.|.........|:...||||:|
  Fly   193 YDAAYCSRSFHAYMNGNQI-----CAGHEER--DTCAGDSGGPLVTRVDFDGVKRYLQLGIVSYG 250

Human   379 -TGCALAQKPGVYTKVSDFREWIFQAI 404
             |.|   |.|||||.|.::..||.:|:
  Fly   251 PTDC---QSPGVYTYVPNYINWIRRAM 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	7/29 (24%)
		Tryp_SPc	163..400	CDD:238113	79/247 (32%)
CG30087	NP_725489.2	Tryp_SPc	42..272	CDD:238113	81/249 (33%)