Protein Alignment HPN and CG43335

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_001247121.1
• Gene: CG43335 / 12798413
• FlyBaseID: FBgn0263040
• Length: 281
• Species: Drosophila melanogaster
• Alignment Length: 295
• Identity: 86/295 - (29%)
• Similarity: 130/295 - (44%)
• Gaps: 41/295 - (13%)

Human   132 LEVISVCD--CPRG--RFLAAICQDCGRRKLPV---DRIVGGRDTSLGRWPWQVSLRYDGAHLCG 189
            |.:||||.  |..|  |.|.   .:||.|.:|.   .||:||.|..:...||...|..:..:.|.
  Fly     7 LVIISVCQWLCRFGESRLLE---PNCGIRTMPSFHRTRIIGGSDAEITSHPWMAYLYNEFHYFCA 68

Human   190 GSLLSGDWVLTAAHCFPERNRV--------LSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPF 246
            |:|::..:|||||||......:        |:|   ..|::.|.:..  ...|...:.|..:.|
  Fly    69 GTLITNQFVLTAAHCIEASKNLTVRLGGSGLTR---SDGSMCQITAE--DYSVSMAIKHKYFTP- 127

Human   247 RDPNSEENSNDIALVHLSSPLPLTEYIQPVCL---PAAGQALVDGKICTVTGWGNTQYYGQQAGV 308
                 ....||||::.|:..:...::|:|:|:   ||....|.||.....||||... ......:
  Fly   128 -----SIMLNDIAMIRLARTVKFYDHIRPICIILDPAVRLLLEDGMTLMATGWGLAD-KRMHPHL 186

Human   309 LQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCG 373
            ||||.:.:::.:||  :..|...|.....|||..|  .:.|.||||||.....:.....|:...|
  Fly   187 LQEAPITVMNRNVC--SKLYDVAITQGQICAGDKE--TNTCLGDSGGPLGGVVNYYGDLRFVQYG 247

Human   374 IVSWG-TGCALAQKPGVYTKVSDFREWIFQAIKTH 407
            |.|:| ..|   :.|.:||.:|.:..||...:..:
  Fly   248 ITSFGDIEC---RSPSIYTDLSTYSGWINMVVSQY 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	12/30 (40%)
		Tryp_SPc	163..400	CDD:238113	70/248 (28%)
CG43335	NP_001247121.1	Tryp_SPc	42..275	CDD:238113	72/251 (29%)