Protein Alignment HPN and CG43110

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_001246396.1
• Gene: CG43110 / 12798330
• FlyBaseID: FBgn0262570
• Length: 483
• Species: Drosophila melanogaster
• Alignment Length: 285
• Identity: 84/285 - (29%)
• Similarity: 124/285 - (43%)
• Gaps: 46/285 - (16%)

Human   138 CDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRY-----DGAH-LCGGSLLSGD 196
            |......||.   |.||  |.||.:|:.|.:.|      |.|.:|     :..| ||||:::..|
  Fly    16 CQLAYSMFLK---QPCG--KTPVPKIISGSNAS------QQSAQYMAGIFNTTHLLCGGTIIHED 69

Human   197 WVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGL-QLGVQAVVYHGGYLPFRDPNSEENSNDIAL 260
            :|||.|||       .|...:|....|....|.. |:.|...:.|..|      ::...:|||||
  Fly    70 FVLTVAHC-------KSTQTLFVRLGAYNINHPTDQIRVIETIAHPQY------SNSTYANDIAL 121

Human   261 VHLSSPLPLTEYIQPVCL---PAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVC 322
            |.|...:.....|||:|:   ...|:.:   :.....|||.|: ..:|:.:||...|...:..:|
  Fly   122 VKLERSVIFNLNIQPICIHLDATLGKQI---RYYNAFGWGRTR-NAEQSDILQRIFVNRTNPMIC 182

Human   323 NGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGT-GCALAQK 386
            :  .:.|....||..||...:|  |.|.||||||.:.:.:..........||.|:|| .|   ..
  Fly   183 H--LYLGMSPDPKQICATTDQG--DTCAGDSGGPLISKITYQGKNFDTQFGITSYGTREC---NG 240

Human   387 PGVYTKVSDFREWIFQAIKTHSEAS 411
            .|:||.||.:..||...:::..:.|
  Fly   241 VGLYTDVSQYSGWIANIVRSKQDRS 265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	7/20 (35%)
		Tryp_SPc	163..400	CDD:238113	72/247 (29%)
CG43110	NP_001246396.1	Tryp_SPc	36..257	CDD:238113	74/250 (30%)