DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and Adcy2

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_112269.2	Gene:	Adcy2 / 81636	RGDID:	619965	Length:	1095	Species:	Rattus norvegicus

Alignment Length:	1602	Identity:	346/1602 - (21%)
Similarity:	565/1602 - (35%)	Gaps:	629/1602 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 AKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILL--CSLMWCLYFVVDGGSED---FWRP 125
            ::.||...:  ..:.:|:...||          |..|::  |..:..::|.:....||   |...
  Rat    33 SRDWLYESY--YCMSQQHPLIVF----------LLLIVMGACLALLAVFFALGLEVEDHVAFLIT 85

  Fly   126 ISSSFSMLSLVTIMALCFTHWDLYREHRTVTSAVTALLLCGASLAFLTYTG--RAFSPLGHFAIC 188
            :.::.::...:.|: :|..  .::::...|.|.|..:.|......|:.:.|  .|:..:..|
  Rat    86 VPTALAIFFAIFIL-VCIE--SVFKKLLRVFSLVIWICLVAMGYLFMCFGGTVSAWDQVSFF--- 144

  Fly   189 LEIVLLIYTALPMPLWLGASTAISYSIAFEMVSHMV---IGCSAIHGGPMHGGGGAAGGSGMEAN 250
            |.|:.::||.||..:    ..||..|| ....||.:   :..||..|...|
  Rat   145 LFIIFVVYTMLPFNM----RDAIIASI-LTSSSHTIVLSVYLSATPGAKEH-------------- 190

  Fly   251 GDPSNRILILRIMAHLSVHLVG-----VHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKM 310
                   |..:|:|::.:.:.|     .|..:|.|. ::.|:......:..|.:||.||:.:|::
  Rat   191 -------LFWQILANVIIFICGNLAGAYHKHLMELA-LQQTYRDTCNCIKSRIKLEFEKRQQERL 247

  Fly   311 IHSVMPPKV-----ADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSIL 370
            :.|::|..:     |:::....||.   ||.:         ..:|:..:|:...|    .|||||
  Rat   248 LLSLLPAHIAMEMKAEIIQRLQGPK---AGQM---------ENTNNFHNLYVKRH----TNVSIL 296

  Fly   371 FADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAIC 435
            :||||||||::|..:..:||.:||:||.:||.:...:.|.:|..||||||||||.|....:||..
  Rat   297 YADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKN 361

  Fly   436 CVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKP 500
            ||:|||.|.:|::.........:.||||||:|.||||::|.::.::||||:||:|||.||:.|.|
  Rat   362 CVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVP 426

  Fly   501 EQVHISQETSSFLGDAYYLEEGEEVFGH-----------RTYFVV---GRRRDFTRTNSLSPSMP 551
            .:||||..|...|..||.:|||:   |.           :||||:   |.||
  Rat   427 GRVHISSVTLEHLNGAYKVEEGD---GEIRDPYLKQHLVKTYFVINPKGERR------------- 475

  Fly   552 ANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMR 616
                                                           ||....|||.|....|||
  Rat   476 -----------------------------------------------SPQHLFRPRHTLDGAKMR 493

  Fly   617 KKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPA 681

  Rat   494 ----------------------------------------------------------------- 493

  Fly   682 AETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEET 746
            |..|....|:.|                  |.:....|               ||..:.:..|
  Rat   494 ASVRMTRYLESW------------------GAAKPFAH---------------LHHRDSMTTE-- 523

  Fly   747 LAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGG 811
                                     |.:..|.|:|.
  Rat   524 -------------------------NGKISTTDVPM----------------------------- 534

  Fly   812 GGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAG 876
                  ||::.            |:|:
  Rat   535 ------GQHNF------------QNRT-------------------------------------- 543

  Fly   877 TSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSS 941

  Rat   544 ----------------------------------------------------------------- 543

  Fly   942 ICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAV 1006
                        :::.|::...:::   ||:
  Rat   544 ------------LRTKSQKKRFEEE---LNE---------------------------------- 559

  Fly  1007 QPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQ 1071
                                            ::|:.: |...:|:.:|....:::.||.|.::.
  Rat   560 --------------------------------RMIQAI-DGINAQKQWLKSEDIQRISLLFYNKN 591

  Fly  1072 LERDFRSKAHRFGAENETEGPPTLATPRYNTYIDIFVGIAVYLCISVSLFLMTQNTVSPSFRLWV 1136
            :|:::|:                .|.|.:..|:.  ....::|||.:...|:...|....|....
  Rat   592 IEKEYRA----------------TALPAFKYYVT--CACLIFLCIFIVQILVLPKTSILGFSFGA 638

  Fly  1137 TLFSCFTGIQVFALFL-FTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCAD 1200
            ...|.     :|.||: |..|:.:....::.|..:..||:
  Rat   639 AFLSL-----IFILFVCFAGQLLQCSKKASTSLMWLLKSS------------------------- 673

  Fly  1201 RIFEAISSWYPWHICLAVLMAMPVLLIIANFLLLDLEQLEAFE---------------------- 1243
                .|.:..||......::...::|.:|.|.:..|...|...
  Rat   674 ----GIIANRPWPRISLTIVTTAIILTMAVFNMFFLSNSEETTLPTANTSNANVSVPDNQASILH 734

  Fly  1244 ----YHYGFLIFVCIVHF--CN-FTQLNCWVRNVLAFLAALCFIGIAVSQLMVYSHNRSDQQQDQ 1301
                :...:.|:.||:..  |: |.::| :...:|..:.||    :..:.:::::|........|
  Rat   735 ARNLFFLPYFIYSCILGLISCSVFLRVN-YELKMLIMMVAL----VGYNTILLHTHAHVLDAYSQ 794

  Fly  1302 ---EASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMK 1363
               :.....:::|......:.|:...||:      |.|:.|...||.|.......:::..::.|:
  Rat   795 VLFQRPGIWKDLKTMGSVSLSIFFITLLV------LGRQSEYYCRLDFLWKNKFKKEREEIETME 853

  Fly  1364 NQADMLLHNIIPKHVAEH-----LKNTAKYSENHHNIAIIFASIVNFNEMYDESYLG--GKEFLR 1421
            |...:||.|::|.|||||     |||...|.:::..:.::||||.:|.|.|.||.:.  |.|.||
  Rat   854 NLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLR 918

  Fly  1422 VLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLD--PSHRGTGDE-----HIHTLMEFSIA 1479
            :|||:|.|||:|||:|:|..||||||||||:|||:||.  ||.....:.     ||.|::||:.|
  Rat   919 LLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAIPSQEHAQEPERQYMHIGTMVEFAYA 983

  Fly  1480 MQEVVDAFNKDLLEFN-LILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQV 1543
            :...:||.||.  .|| ..||:|:|.|.|.|||||..|..|||||:.|||||||||||:.::|||
  Rat   984 LVGKLDAINKH--SFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQV 1046

  Fly  1544 GKD-CLPFLTNRYEFEPRGSVYVKGKDHMEVFLYTTRRDNPL 1584
            .:: .|...|..|....||.:.||||..::.:...|.....|
  Rat  1047 TEETSLILQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSL 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	89/220 (40%)
		Guanylate_cyc	361..535	CDD:278633	85/187 (45%)
		CYCc	1362..1556	CDD:214485	102/209 (49%)
		Guanylate_cyc	1388..1575	CDD:278633	95/197 (48%)
Adcy2	NP_112269.2	AC_N	<37..264	CDD:318454	54/271 (20%)
		Guanylate_cyc	285..469	CDD:306677	87/190 (46%)
		DUF1053	499..603	CDD:399378	28/411 (7%)
		Guanylate_cyc	882..1081	CDD:306677	95/200 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810