DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and Gucy2d

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_077356.1	Gene:	Gucy2d / 79222	RGDID:	620438	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	328	Identity:	90/328 - (27%)
Similarity:	151/328 - (46%)	Gaps:	73/328 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 LIMNLVRMRGTFMKVGQNLLVRR--QLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLP 338
            :|.:::||...:....::|:..|  :||.|||..::::..::||.||:.|          ..|..
  Rat   819 IIDSMLRMLEQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVAEAL----------KMGTS 873

  Fly   339 PESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDL 403
            .|..|                    .|.|::.|:||||||.:|:.....::|::||||:..||.:
  Rat   874 VEPEY--------------------FEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAI 918

  Fly   404 CSLSGCEKISTLGDCYYCVSGCPEPRAD-HAICCVEMGLGMIDAMRCFDAQRH---EGVKMRVGV 464
            .......|:.|:||.|...||.|:.... ||.....|.|.::.|:..| ..||   ..|::|:|:
  Rat   919 IGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSF-RMRHMPEVPVRIRIGL 982

  Fly   465 HTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSF---LGDAYYLE------ 520
            |:|..:.|:||....::.::.:.|:.|::|||:|.|.::|::..|...   |...:.:|
  Rat   983 HSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNMSTVRILRALDQGFQMECRGRTE 1047

  Fly   521 -EGEEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGA--HGASLSQSATNVSAVQPN 582
             :|:.|  ..||::|||    ...|...|..|.       |.|||  ||.||.:
  Rat  1048 LKGKGV--EDTYWLVGR----VGFNKPIPKPPD-------LQPGASNHGISLQE----------- 1088

  Fly   583 VPP 585
            :||
  Rat  1089 IPP 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	62/222 (28%)
		Guanylate_cyc	361..535	CDD:278633	56/187 (30%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
Gucy2d	NP_077356.1	PBP1_sensory_GC_DEF-like	58..434	CDD:380594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..552
		PK_GC-2D	540..814	CDD:270945
		HNOBA	<823..868	CDD:400168	13/44 (30%)
		CYCc	848..1039	CDD:214485	62/221 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1069..1108		12/41 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900