DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and Gucy2g

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001074545.1	Gene:	Gucy2g / 73707	MGIID:	106025	Length:	1100	Species:	Mus musculus

Alignment Length:	253	Identity:	77/253 - (30%)
Similarity:	128/253 - (50%)	Gaps:	48/253 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 RQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMH 362
            |:|..||:..||::.:::|..|.:.|:         ||                 ||: .|.|
Mouse   861 RELVAEKRKVEKLLSTMLPSFVGEQLI---------AG-----------------KSV-EPEH-- 896

  Fly   363 SMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCP- 426
             .|:|:|.|:||||||::.|..:..|:|::||||:..||.........|:.|:||.|...||.|
Mouse   897 -FESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQSHDVYKVETIGDAYMVASGLPI 960

  Fly   427 EPRADHAICCVEMGLGMIDAMRCFDA--QRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVS 489
            ...|.||.....|.|.::.....|..  ...|.:|:|:|:|||.|:.|:||....::.::.:.|:
Mouse   961 RNGAQHADEIATMALHLLSVTTHFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVN 1025

  Fly   490 LANKMESSGKPEQVHISQETSSFL--GDAYYLE---------EGEEVFGHRTYFVVGR 536
            :|::||||..|.::|:||.|:..|  ...|:|:         :||:.    |:::.|:
Mouse  1026 MASRMESSSLPLRIHVSQSTAGALLAAGGYHLQKRGTISVKGKGEQT----TFWLKGK 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	69/220 (31%)
		Guanylate_cyc	361..535	CDD:278633	61/187 (33%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
Gucy2g	NP_001074545.1	PBP1_GC_G-like	47..436	CDD:380595
		PK_GC	555..829	CDD:270894
		CYCc	865..1055	CDD:214485	69/219 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900