Protein Alignment Ac13E and Adcy3

DIOPT Version :10

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_570135.2
• Gene: Adcy3 / 64508
• RGDID: 71009
• Length: 1144
• Species: Rattus norvegicus
• Alignment Length: 1626
• Identity: 376/1626 - (23%)
• Similarity: 574/1626 - (35%)
• Gaps: 622/1626 - (38%)

  Fly    47 GRRH--------SCCSVMLPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYIL 103
            ||.|        ||  :.|| .|.|..        |....||..|| :.|.  |.|:...|..::
  Rat    33 GRTHEISVRNSGSC--LCLP-RFMRLT--------FVPESLENLYQ-TYFK--RQRHETLLVLVV 83

  Fly   104 LCSLMWCLYFVVDGG---SEDFWRPIS-SSFSMLSLVTIMALCFTHWDLYREHRTVTSAVTALLL 164
            ..:|..| |.||...   |.|...|:. :...::..:.:..||.......|..|.|...:..||:
  Rat    84 FAALFDC-YVVVMCAVVFSSDKLAPLMVAGVGLVLDIILFVLCKKGLLPDRVSRKVVPYLLWLLI 147

  Fly   165 CGASLAFLTYTGRAFS-------PLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVSH 222
               :....:|.|..||       .:|..|.   .|...:..||:.|    |..:..|:...:|..
  Rat   148 ---TAQIFSYLGLNFSRAHAASDTVGWQAF---FVFSFFITLPLSL----SPIVIISVVSCVVHT 202

  Fly   223 MVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTF 287
            :|:|.:            .|.....|..|....|.::..:..:|...:||:....|...:.|..|
  Rat   203 LVLGVT------------VAQQQQDELEGMQLLREILANVFLYLCAIIVGIMSYYMADRKHRKAF 255

  Fly   288 MKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDV 352
            ::..|:|.|:..||.:.|.:|.::.|::|..|||.:|.:                 |:...|...
  Rat   256 LEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKD-----------------MKKDESQKD 303

  Fly   353 KSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGD 417
            :..|...:|:..||||||||||||||::||..:|::||::||:||.|||.|.:.....:|..|||
  Rat   304 QQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGD 368

  Fly   418 CYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFD 482
            ||||:.|.|:.|.|||:|.:.|||.|::|:.....:...||.|||||||||||.|::|.:|.::|
  Rat   369 CYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYD 433

  Fly   483 VWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGE--------EVFGHRTYFVVGRRRD 539
            |||.||::|||||:.|.|.:|||||.|...|...:.:|.|:        :..|..||.::..:.:
  Rat   434 VWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLDEKGIETYLIIASKPE 498

  Fly   540 FTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSM 604
            ..:|                          :|:..|.||: ||..|||         .||
  Rat   499 VKKT--------------------------AQNGLNGSAL-PNGAPAS---------KPS----- 522

  Fly   605 RPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSL-------- 661
                                       .||                :|.||...||.
  Rat   523 ---------------------------SPA----------------LIETKEPNGSAHASGSTSE 544

  Fly   662 DSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKERER 726
            :::||...:.      ||.....|.:::|            :||.:|.          :|
  Rat   545 EAEEQEAQAD------NPSFPNPRRRLRL------------QDLADRV----------VD----- 576

  Fly   727 EREKEKEELHQHNQLNPEE------------------TLAFMDNQMQNGNGCGYQQLPVLVESNH 773
                ..|:.|:.|||..|.                  |:.|||.:|:.
  Rat   577 ----ASEDEHELNQLLNEALLERESAQVVKKRNTFLLTMRFMDPEMET----------------- 620

  Fly   774 RTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGC----CSPGQYSMYDDIID---VRS 831
                                   ..||.:..::|.:....|    |:    :|.:.:||   :.:
  Rat   621 -----------------------RYSVEKEKQSGAAFSCSCVVLFCT----AMVEILIDPWLMTN 658

  Fly   832 YISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRAST 896
            |:                                                              |
  Rat   659 YV--------------------------------------------------------------T 661

  Fly   897 LATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRS 961
            ...|......|       :.|.:.|         |||....:                |..:..|
  Rat   662 FVVGEVLLLIL-------TICSMAA---------IFPRAFPK----------------KLVAFSS 694

  Fly   962 SIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLA 1026
            .|.:..:|.|..|:                        |.:.:.|.           :.:.|.|
  Rat   695 WIDRTRWARNTWAM------------------------LAIFILVM-----------ANVVDML- 723

  Fly  1027 ACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEG 1091
            :|||                       |.:.|       |..:..:|.|        |.
  Rat   724 SCLQ-----------------------YYMGP-------YNVTTGIELD--------GG------ 744

  Fly  1092 PPTLATPRYNTYIDIFVGIAVYLCISVS-------LFLMTQNTVSPSFRLWVTLFSCFTGIQVFA 1149
              .:..|:|..|:.:...||..:.:.||       :.|:|....:.:...|..:|..:.
  Rat   745 --CMENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGAVTAINLYAWCPVFDEYD------ 801

  Fly  1150 LFLFTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHI 1214
                             ..||:.|.:....||:.:..:.||            .....|..|
  Rat   802 -----------------HKRFQEKDSPMVALEKMQVLSTPG------------LNGTDSRLP--- 834

  Fly  1215 CLAVLMAMPVLLIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCF 1279
                                    |...:|....::||.::.|..|::
  Rat   835 ------------------------LVPSKYSMTVMMFVMMLSFYYFSR----------------- 858

  Fly  1280 IGIAVSQLMVYSHNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRL 1344
                                                 |||    .|...:.:|    :.|:
  Rat   859 -------------------------------------HVE----KLARTLFLW----KIEV---- 874

  Fly  1345 TFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHLKNTAK-----YSENHHNIAIIFASIVN 1404
                    :..|.||..|:...:.|:.|::|:|||.|...:.|     ||:::..|.::|||:.|
  Rat   875 --------HDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASLPN 931

  Fly  1405 FNEMYDESYL--GGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTGD 1467
            |.:.|.|..:  ||.|.||.|||:|.|||.||..|:||.:.||||||||:|||||:.|.....|.
  Rat   932 FADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGF 996

  Fly  1468 --------------EHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLY 1518
                          :|:..|.:|::||::.:...|..... |.:||||||.|.|.|||||..|.:
  Rat   997 TSSSKEEKSDKERWQHLADLADFALAMKDTLTNINNQSFN-NFMLRIGMNKGGVLAGVIGARKPH 1060

  Fly  1519 YDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTN-RYEFEPRGSVYVKGKDHMEVFLYTTRRDN 1582
            |||||:.|||||||:|||:...|||.::....|.. .:.|..||.::||||..:..| :...||.
  Rat  1061 YDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTF-FLKGRDR 1124

  Fly  1583 P 1583
            |
  Rat  1125 P 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	95/215 (44%)
		PHA03307	836..>1015	CDD:223039	16/178 (9%)
		Guanylate_cyc	1388..1575	CDD:425528	89/203 (44%)
Adcy3	NP_570135.2	AcyC	105..499	CDD:441717	138/432 (32%)
		Guanylate_cyc	310..494	CDD:425528	89/183 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	504..563		22/122 (18%)
		Guanylate_cyc	914..1121	CDD:425528	90/208 (43%)