DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ac13E and Adcy3

DIOPT Version :9

Sequence 1:NP_001259575.1 Gene:Ac13E / 32485 FlyBaseID:FBgn0022710 Length:1703 Species:Drosophila melanogaster
Sequence 2:NP_570135.2 Gene:Adcy3 / 64508 RGDID:71009 Length:1144 Species:Rattus norvegicus


Alignment Length:1626 Identity:376/1626 - (23%)
Similarity:574/1626 - (35%) Gaps:622/1626 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 GRRH--------SCCSVMLPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYIL 103
            ||.|        ||  :.|| .|.|..        |....||..|| :.|.  |.|:...|..::
  Rat    33 GRTHEISVRNSGSC--LCLP-RFMRLT--------FVPESLENLYQ-TYFK--RQRHETLLVLVV 83

  Fly   104 LCSLMWCLYFVVDGG---SEDFWRPIS-SSFSMLSLVTIMALCFTHWDLYREHRTVTSAVTALLL 164
            ..:|..| |.||...   |.|...|:. :...::..:.:..||.......|..|.|...:..||:
  Rat    84 FAALFDC-YVVVMCAVVFSSDKLAPLMVAGVGLVLDIILFVLCKKGLLPDRVSRKVVPYLLWLLI 147

  Fly   165 CGASLAFLTYTGRAFS-------PLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVSH 222
               :....:|.|..||       .:|..|.   .|...:..||:.|    |..:..|:...:|..
  Rat   148 ---TAQIFSYLGLNFSRAHAASDTVGWQAF---FVFSFFITLPLSL----SPIVIISVVSCVVHT 202

  Fly   223 MVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTF 287
            :|:|.:            .|.....|..|....|.::..:..:|...:||:....|...:.|..|
  Rat   203 LVLGVT------------VAQQQQDELEGMQLLREILANVFLYLCAIIVGIMSYYMADRKHRKAF 255

  Fly   288 MKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDV 352
            ::..|:|.|:..||.:.|.:|.::.|::|..|||.:|.:                 |:...|...
  Rat   256 LEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKD-----------------MKKDESQKD 303

  Fly   353 KSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGD 417
            :..|...:|:..||||||||||||||::||..:|::||::||:||.|||.|.:.....:|..|||
  Rat   304 QQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGD 368

  Fly   418 CYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFD 482
            ||||:.|.|:.|.|||:|.:.|||.|::|:.....:...||.|||||||||||.|::|.:|.::|
  Rat   369 CYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYD 433

  Fly   483 VWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGE--------EVFGHRTYFVVGRRRD 539
            |||.||::|||||:.|.|.:|||||.|...|...:.:|.|:        :..|..||.::..:.:
  Rat   434 VWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLDEKGIETYLIIASKPE 498

  Fly   540 FTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSM 604
            ..:|                          :|:..|.||: ||..|||         .||     
  Rat   499 VKKT--------------------------AQNGLNGSAL-PNGAPAS---------KPS----- 522

  Fly   605 RPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSL-------- 661
                                       .||                :|.||...||.        
  Rat   523 ---------------------------SPA----------------LIETKEPNGSAHASGSTSE 544

  Fly   662 DSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKERER 726
            :::||...:.      ||.....|.:::|            :||.:|.          :|     
  Rat   545 EAEEQEAQAD------NPSFPNPRRRLRL------------QDLADRV----------VD----- 576

  Fly   727 EREKEKEELHQHNQLNPEE------------------TLAFMDNQMQNGNGCGYQQLPVLVESNH 773
                ..|:.|:.|||..|.                  |:.|||.:|:.                 
  Rat   577 ----ASEDEHELNQLLNEALLERESAQVVKKRNTFLLTMRFMDPEMET----------------- 620

  Fly   774 RTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGC----CSPGQYSMYDDIID---VRS 831
                                   ..||.:..::|.:....|    |:    :|.:.:||   :.:
  Rat   621 -----------------------RYSVEKEKQSGAAFSCSCVVLFCT----AMVEILIDPWLMTN 658

  Fly   832 YISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRAST 896
            |:                                                              |
  Rat   659 YV--------------------------------------------------------------T 661

  Fly   897 LATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRS 961
            ...|......|       :.|.:.|         |||....:                |..:..|
  Rat   662 FVVGEVLLLIL-------TICSMAA---------IFPRAFPK----------------KLVAFSS 694

  Fly   962 SIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLA 1026
            .|.:..:|.|..|:                        |.:.:.|.           :.:.|.| 
  Rat   695 WIDRTRWARNTWAM------------------------LAIFILVM-----------ANVVDML- 723

  Fly  1027 ACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEG 1091
            :|||                       |.:.|       |..:..:|.|        |.      
  Rat   724 SCLQ-----------------------YYMGP-------YNVTTGIELD--------GG------ 744

  Fly  1092 PPTLATPRYNTYIDIFVGIAVYLCISVS-------LFLMTQNTVSPSFRLWVTLFSCFTGIQVFA 1149
              .:..|:|..|:.:...||..:.:.||       :.|:|....:.:...|..:|..:.      
  Rat   745 --CMENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGAVTAINLYAWCPVFDEYD------ 801

  Fly  1150 LFLFTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHI 1214
                             ..||:.|.:....||:.:..:.||            .....|..|   
  Rat   802 -----------------HKRFQEKDSPMVALEKMQVLSTPG------------LNGTDSRLP--- 834

  Fly  1215 CLAVLMAMPVLLIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCF 1279
                                    |...:|....::||.::.|..|::                 
  Rat   835 ------------------------LVPSKYSMTVMMFVMMLSFYYFSR----------------- 858

  Fly  1280 IGIAVSQLMVYSHNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRL 1344
                                                 |||    .|...:.:|    :.|:    
  Rat   859 -------------------------------------HVE----KLARTLFLW----KIEV---- 874

  Fly  1345 TFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHLKNTAK-----YSENHHNIAIIFASIVN 1404
                    :..|.||..|:...:.|:.|::|:|||.|...:.|     ||:::..|.::|||:.|
  Rat   875 --------HDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASLPN 931

  Fly  1405 FNEMYDESYL--GGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTGD 1467
            |.:.|.|..:  ||.|.||.|||:|.|||.||..|:||.:.||||||||:|||||:.|.....|.
  Rat   932 FADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGF 996

  Fly  1468 --------------EHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLY 1518
                          :|:..|.:|::||::.:...|..... |.:||||||.|.|.|||||..|.:
  Rat   997 TSSSKEEKSDKERWQHLADLADFALAMKDTLTNINNQSFN-NFMLRIGMNKGGVLAGVIGARKPH 1060

  Fly  1519 YDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTN-RYEFEPRGSVYVKGKDHMEVFLYTTRRDN 1582
            |||||:.|||||||:|||:...|||.::....|.. .:.|..||.::||||..:..| :...||.
  Rat  1061 YDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTF-FLKGRDR 1124

  Fly  1583 P 1583
            |
  Rat  1125 P 1125

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac13ENP_001259575.1 CYCc 302..518 CDD:214485 95/215 (44%)
Guanylate_cyc 361..535 CDD:278633 89/181 (49%)
CYCc 1362..1556 CDD:214485 91/215 (42%)
Guanylate_cyc 1388..1575 CDD:278633 89/203 (44%)
Adcy3NP_570135.2 AC_N <44..303 CDD:318454 70/312 (22%)
Guanylate_cyc 310..494 CDD:306677 89/183 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 504..563 22/122 (18%)
Guanylate_cyc 914..1121 CDD:306677 90/208 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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