DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and CG34357

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster

Alignment Length:	774	Identity:	179/774 - (23%)
Similarity:	285/774 - (36%)	Gaps:	253/774 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 KVGQNL--LVR---RQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRA 348
            |...||  |:|   .||::|::..|::::.::|..||:.|     ..||   .:.||
  Fly  1056 KYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKL-----KMGL---AVDPE-------- 1104

  Fly   349 SNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKIS 413
                          ...:|:|.|:||||||.:::..:..|:|::||||:..||...:.....|:.
  Fly  1105 --------------EFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVE 1155

  Fly   414 TLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGV--KMRVGVHTGTVLCGIVGT 476
            |:||.|..|||.|....|||.....|.|.::.....|:.:...||  ::|:|:|||....|:||.
  Fly  1156 TIGDAYMVVSGLPVKIPDHAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGL 1220

  Fly   477 RRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDA---YYLE-------EGEEVFGHRTY 531
            ...::.::.:.|:.|::|||:|...::|:||||...| ||   |.:|       :|:.:.  .|:
  Fly  1221 TMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRL-DARGGYAIEPRGLIDIKGKGMM--NTF 1282

  Fly   532 FVVGRRRDFTRTNSLSPSMPA-NATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSS 595
            :::|::       .....:|| ...|.|      ||       .:.|.::.::...:...:..:|
  Fly  1283 WLLGKK-------GFDKPLPAPPPIGES------HG-------LDESLIRNSITLKAQANKSRTS 1327

  Fly   596 LNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPG- 659
            .|||         :|.|..:..:|.    :|:..|..|..|.             :.:..:||.
  Fly  1328 TNPS---------SSQSSSLAGESV----EVKVEITPPTNAD-------------LASGTNLPNS 1366

  Fly   660 -SLDSDEQPPVSP-----PLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLT----------NR 708
             ||||:....:||     |..|....|::.:....||            .:||          ||
  Fly  1367 YSLDSNSTNTISPNATLCPEFPGKTTPSSTSPQSRKL------------SELTPENLLNPNSFNR 1419

  Fly   709 --SSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVES 771
              ||.|||||  .|.|:.|...:......| :..|:|.|
  Fly  1420 LPSSTGGSSS--RLYKKIEEMMDLSSPYNH-YKCLSPSE-------------------------- 1455

  Fly   772 NHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCS------------------PG 818
            ::.||..|             ...|..||......|.:|||.|.|                  ||
  Fly  1456 SNLTQFYD-------------GKYLYGSVAGGAGGGQAGGGACASIALSGSGCGGGASRFDSKPG 1507

  Fly   819 QYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGA------------ 871
            ...:      :|...|..|.|....|....::......:..|:.|....||.:
  Fly  1508 SSRL------LRRQFSLDRDDQQAKGEQQHHQHSLQANTYSGLVGGCGGGVKSSMLDIPLLHDTT 1566

  Fly   872 ------------EGRAGTSQTAPPVEQ---SPLPRPRASTLAT--GRPTPNSLEPGPSSTSPCCL 919
                        :..|..:|....:|:   ||......|:|.:  .|..|::||    :.||
  Fly  1567 RSPKGTLTRSHKQNSASITQDLEKIEEIPLSPASSQHHSSLDSNLNRSPPSTLE----AQSP--- 1624

  Fly   920 PAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQH 978
            |.|..|       ||..|..:|..||.|                ...|||.|..:.|.|
  Fly  1625 PLPPMS-------PPQLSAPTSPAPSRT----------------LNGIYAHNSNSTSSH 1660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	66/220 (30%)
		Guanylate_cyc	361..535	CDD:278633	60/185 (32%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	67/222 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810