Protein Alignment Ac13E and adcy3a

DIOPT Version :10

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_009290286.2
• Gene: adcy3a / 571825
• ZFINID: ZDB-GENE-111027-6
• Length: 1119
• Species: Danio rerio
• Alignment Length: 1602
• Identity: 366/1602 - (22%)
• Similarity: 564/1602 - (35%)
• Gaps: 606/1602 - (37%)

  Fly    47 GRRH------SCCSVMLPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILLC 105
            ||.|      |.|.:.|| .|.|..        |....||..|| :.|.  |.|:...|..::..
Zfish    33 GRTHEVTVRSSGCCLCLP-RFMRLT--------FAPDSLENLYQ-TYFR--RQRHETLLVLVVFA 85

  Fly   106 SLMWCLYFV---VDGGSEDFWRPISSSFSMLSLVTIMALC---------------FTHWDLYREH 152
            :|..|...|   |...::.......:|..:.:.|.:..||               :..|.|
Zfish    86 ALFDCYIIVMCTVLYTADKLASVAVASVGLAADVLLYLLCRYGLLPDRVTRRLVPYALWVL---- 146

  Fly   153 RTVTSAVTALLLCGASLAFL-------TYTGRAFSPLGHFAICLEIVLLIYTALPMPLWLGASTA 210
                  :.|.:.|...|.|.       |...:||.....|             |.:||.|.....
Zfish   147 ------IAAQIFCYLGLNFARFHQPSDTVGWQAFFSFSFF-------------LTLPLRLTPIVL 192

  Fly   211 ISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHV 275
            |: |::.. |..:|:|.:..........|.|.|            |.|:..::.::....|||..
Zfish   193 IT-SVSCG-VHTLVLGVTIAQQQQEDIQGAALG------------RQLLANMVIYVCAITVGVMS 243

  Fly   276 LIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPE 340
            ..|...:.|..|::..|:|.|:..||.:.|.:|:::.|::|..:||.:|.:
Zfish   244 YYMADRKHRKAFLEARQSLEVKLNLEEQSQQQERLLLSILPKHIADEMLQD-------------- 294

  Fly   341 SHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCS 405
               |:..||......|...:|:..||||||||||||||::||:.:|::||::||:||.|||.|.:
Zfish   295 ---MKKEASQKEMQQFNTMYMYRHENVSILFADIVGFTQLSSSCSAQELVKLLNELFARFDKLAA 356

  Fly   406 LSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVL 470
            .....:|..|||||||:.|.|:.|.|||.|.:.|||.|::|:.....:....|.||||||:|.||
Zfish   357 KYHQLRIKILGDCYYCICGLPDYREDHAACSIMMGLAMVEAISYVREKTQTDVDMRVGVHSGMVL 421

  Fly   471 CGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGE--------EVFG 527
            .|::|.:|.::||||.||::|||||:.|.|.:|||||.|...|...:.:|.|.        :..|
Zfish   422 GGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQNTLECLHGEFDVEPGNGGDRCEYLKERG 486

  Fly   528 HRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQL 592
            ..||.||               :|....|.:    |.:|..||                     :
Zfish   487 IETYLVV---------------LPKGPVGKN----GINGVKLS---------------------V 511

  Fly   593 SSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSL 657
            :||...||:|......                   .|.:|.|.                 ||...
Zfish   512 TSSNGNSPLLINTTEC-------------------NGSVHTAC-----------------TTPED 540

  Fly   658 PGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDK 722
            |..||:....|..|      ||     |.:::|:            ||.
Zfish   541 PEELDTRVVNPSFP------NP-----RRRLRLR------------DLA---------------- 566

  Fly   723 EREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVL 787
            ||..:.::.::||                |::.|         ..|:|..
Zfish   567 ERVIDAQENEQEL----------------NKLLN---------EALLERE--------------- 591

  Fly   788 HHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQ 852
                |..||                    .|:|:
Zfish   592 ----TVQAL--------------------KGKYT------------------------------- 601

  Fly   853 CGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPC 917
                                .|.....|.|.:|                 |..|:|
Zfish   602 --------------------NRLSLRFTDPELE-----------------TRFSVE--------- 620

  Fly   918 CLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSG 982
                                          ..|.||...:.  |.:.....|:.:..|....|:.
Zfish   621 ------------------------------KEKQSGAAFSC--SCVVLLFTAVMEALIDPWLVAN 653

  Fly   983 YFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDN 1047
            |.|                  |||.....|::..||      |||.
Zfish   654 YVT------------------LAVGEVLLLILTICS------LAAI------------------- 675

  Fly  1048 ARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGPPTLATPRYNTYIDIFVGIAV 1112
                           |...|..|.:.                          ::|:|| ....|.
Zfish   676 ---------------FPRVFPKRLVS--------------------------FSTWID-HTRWAR 698

  Fly  1113 YLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTS 1177
            ......::|::|...:       |.:.||                             |:..|::
Zfish   699 NTWAMAAIFIVTLADI-------VDMLSC-----------------------------RAPQTST 727

  Fly  1178 EDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLIIANFLLLDLEQLEAF 1242
            .     |..|.|........||:.     ..:|.:         :.||.:||..:|:.:..
Zfish   728 V-----ESTAVPPVVTAIRGCAEN-----PKYYSF---------IAVLALIATTMLVQVSH---- 769

  Fly  1243 EYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVYSHNRSDQQQDQEASNFI 1307
                                        :..|..:..|.:|...:.:||.:::..         :
Zfish   770 ----------------------------MVKLTLMLLITVATGAVNIYSWSQTFD---------L 797

  Fly  1308 QEIKWFQDYHVEIY-----LDLLLILVLV--WFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQ 1365
            .::..|::|.|.:.     :.:::.:::|  ::.:|..|...|..|......::.|.:|..|:..
Zfish   798 YDLTRFKEYRVNLVPSKYTMSVMIFIMMVSFYYFSRHVEKLARTLFLWKIEVHEQKEKVYEMRRW 862

  Fly  1366 ADMLLHNIIPKHVAEHLKNTAK-----YSENHHNIAIIFASIVNFNEMYDESYL--GGKEFLRVL 1423
            .:.|:.|::|:|||.|...:.|     ||:::..|.::||||.||::.|.|..:  ||.|.||.|
Zfish   863 NEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASIPNFSDFYTEESINNGGIECLRFL 927

  Fly  1424 NELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTGD--------------EHIHTLM 1474
            ||:|.|||.||..|:||.:.||||||||:|||||:...:...|.              :|:..|.
Zfish   928 NEIISDFDSLLDEPQFRCITKIKTIGSTYMAASGVTSDNNTNGYACMKKEEISDRERWQHLADLA 992

  Fly  1475 EFSIAMQEVVDAFNKDLLEF-NLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLP 1538
            :|::||:  |...|.:...| |.:||||:|.|.|.|||||..|.::||||:.|||||||:|||:.
Zfish   993 DFALAMK--VTLMNINYQSFNNFMLRIGLNKGAVLAGVIGARKPHFDIWGNTVNVASRMESTGVM 1055

  Fly  1539 NRIQVGKDCLPFLTN-RYEFEPRGSVYVKGKDHMEVFLYTTR 1579
            ..|||.:||...|.: .:.|..||.::||||..:..:....|
Zfish  1056 GNIQVVEDCYCILKDYGFRFVRRGPIFVKGKGELLTYFLKGR 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	92/215 (43%)
		PHA03307	836..>1015	CDD:223039	20/178 (11%)
		Guanylate_cyc	1388..1575	CDD:425528	91/204 (45%)
adcy3a	XP_009290286.2	None