DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and adcy6a

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	XP_017209219.1	Gene:	adcy6a / 570652	ZFINID:	ZDB-GENE-060221-1	Length:	1203	Species:	Danio rerio

Alignment Length:	1629	Identity:	374/1629 - (22%)
Similarity:	546/1629 - (33%)	Gaps:	680/1629 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 AAKSW-------LDPKFDSPVLEEQYQASVFPHVRMRYRFTLS----------YILLCSLMWCLY 112
            ||..|       ...||.|..||..||         ||.|.|:          .:::|.:|  |.
Zfish   142 AADCWQRVVRVFQSKKFQSRKLERLYQ---------RYFFRLNQSSLTMLMGVLVIVCGVM--LT 195

  Fly   113 FVVDGGSEDFWRPISSSFSMLSLVTIMALCFTHWDLYREHRTVTS-AVTALLLCGASLAFLTYTG 176
            |....|..|.......|.:|...:.:|.:|..: ..::::..:.| .|..:|:.......|....
Zfish   196 FHCIHGPPDVVYASVLSVAMALFLALMVVCNRN-GFHQDYMWMVSYLVIGVLIIVQVFGVLMVAP 259

  Fly   177 RAFSPLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGA 241
            |:.|....:::.  .:.:|||.||:.:   .:..:|..:           .||||
Zfish   260 RSASEGIWWSVF--FIYIIYTLLPVRM---RAAVLSGGV-----------LSAIH---------- 298

  Fly   242 AGGSGMEANGDPSN--RILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEK 304
             ..:....|.|...  :.|...::..|..:::|:.......|..|..|.:....:..|..|:.|.
Zfish   299 -LLTTWRINQDDEFLWKQLSANVLIFLCTNIIGICTHYPAEVSQRQAFQETRGYIQARLHLQREN 362

  Fly   305 QLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKS---LFRPFHMHSMEN 366
            |.:|:::.||:|..||                       |..:|..:.|.   :|...::...:|
Zfish   363 QQQERLLLSVLPRHVA-----------------------MEMKADINAKKEDMMFHKIYIQKHDN 404

  Fly   367 VSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRAD 431
            ||||||||.|||.::|..||::||..||:||.|||.|.|.:.|.:|..||||||||||.||||||
Zfish   405 VSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLASENHCLRIKILGDCYYCVSGLPEPRAD 469

  Fly   432 HAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMES 496
            ||.||||||:.||:|:..........|.||||:|:|.|.||::|.|:.:||||||||:|||.||:
Zfish   470 HAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEA 534

  Fly   497 SGKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLL 561
            .||..::||::.|..:|...|.:|.|   ||       |.|..:.:.||:          .:.|:
Zfish   535 GGKAGRIHITKATLQYLNGDYEVEPG---FG-------GERNAYLKENSI----------ETFLV 579

  Fly   562 PG---------AHGASLSQSATNVS-AVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMR 616
            .|         |..|.:.::.||.: |:.|...|.                             |
Zfish   580 LGCSQKRKDEKAMMAKMQRTRTNSNEALVPRWVPD-----------------------------R 615

  Fly   617 KKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPA 681
            ..|:::|..|.|.:      ||.
Zfish   616 SFSRTKDSKVFRQM------GID------------------------------------------ 632

  Fly   682 AETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEET 746
             ||.||                  .||    |:..|                       ||||:.
Zfish   633 -ETSSK------------------DNR----GAQEA-----------------------LNPEDE 651

  Fly   747 LAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGG 811
            :
Zfish   652 V---------------------------------------------------------------- 652

  Fly   812 GGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAG 876
                        |:.:                ||:...||
Zfish   653 ------------DEFL----------------GRAIDARS------------------------- 664

  Fly   877 TSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSS 941

Zfish   665 ----------------------------------------------------------------- 664

  Fly   942 ICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAV 1006

Zfish   665 ----------------------------------------------------------------- 664

  Fly  1007 QPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQ 1071
                                  :.||||..                       ::||.|.|::..
Zfish   665 ----------------------IDQLRKDH-----------------------VKKFLLTFQTSS 684

  Fly  1072 LERDFRSKA-HRFGAENETEG--------------------PPTLATPRYNTYIDIFVGI----- 1110
            ||:.:..|. .|||      |                    |.||.  ....||.||:.:
Zfish   685 LEKKYAKKVDDRFG------GYVACTLLVFCFISFIQIVVFPHTLV--MLGIYISIFIILANILF 741

  Fly  1111 --AVYLCISVSLFLMTQNTVSPSF---RLWVTLFSCFTGIQVFALFLFTRQMCRRQ--------- 1161
              |:|.|  |.||.....|||...   |...||...||.|.||.........|..|
Zfish   742 ICAIYSC--VKLFPAAMQTVSKKIVQSRTNSTLVGVFTIILVFISAFVNMFSCDTQKLVDCVAKQ 804

  Fly  1162 ---SGSNVS-----NRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAV 1218
               |...|:     |..||.:        |.....|...|   ||      ....::.:.:.|.:
Zfish   805 LNWSSEMVTPCIIHNMSRSVA--------DGLSICPNNTP---SC------PFPEYFSYSVLLTL 852

  Fly  1219 L-------------MAMPVLLIIANFLLLDLEQLEAFEYHYGF-----LIFVCIVHFCNF--TQL 1263
            |             :|:.:|:.:...||::..::..|:....|     |:|...:.:.||  |..
Zfish   853 LACSVFLQISSIGKLALMLLIQLTFLLLVEWPEVALFDNADLFVTANALVFNETLQWSNFNTTTE 917

  Fly  1264 NCWVRNVLAFLAALCFIGIAVSQLMVYSHNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLIL 1328
            .|..|.....|..:..:.:.|..|.:|.|   .||.:..|
Zfish   918 QCTFRVTKVSLKVMTPVILTVFVLALYLH---AQQVESTA------------------------- 954

  Fly  1329 VLVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHL-----KNTAKY 1388
                          ||.|.....|.::|..::.::.....|||||:||.||.|.     :|...|
Zfish   955 --------------RLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELY 1005

  Fly  1389 SENHHNIAIIFASIVNFNEMYDESYLG--GKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGST 1451
            .::...:|::||||.||:|.|.|....  |.|.||:|||:|.||||::|..::|.:|||||||||
Zfish  1006 YQSCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEEKYRQLEKIKTIGST 1070

  Fly  1452 FMAASGL-DPSHRGTGDEHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTS 1515
            :|||||| |.::...|..||..|.::::.::|.:...|:.... |..::||:|||.|.|||||..
Zfish  1071 YMAASGLNDSTYDKEGRSHITALADYAMHLREQMKYINEHSFN-NFQMKIGLNIGPVVAGVIGAR 1134

  Fly  1516 KLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNR-YEFEPRGSVYVKGKDHMEVFLYTTR 1579
            |..|||||:.|||||||||||:|:||||..|....|.:: |:.|.||.:.||||..|..:..
Zfish  1135 KPQYDIWGNTVNVASRMDSTGVPDRIQVTTDLHQVLHSKGYQLECRGVIKVKGKGEMTTYFL--- 1196

  Fly  1580 RDNP 1583
            .|.|
Zfish  1197 NDGP 1200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	98/218 (45%)
		Guanylate_cyc	361..535	CDD:278633	91/173 (53%)
		CYCc	1362..1556	CDD:214485	94/202 (47%)
		Guanylate_cyc	1388..1575	CDD:278633	92/190 (48%)
adcy6a	XP_017209219.1	AC_N	<97..395	CDD:318454	61/314 (19%)
		Guanylate_cyc	397..570	CDD:306677	93/182 (51%)
		DUF1053	609..696	CDD:310728	37/501 (7%)
		Guanylate_cyc	1004..1197	CDD:306677	92/196 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810