DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and adcy1b

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001161822.1	Gene:	adcy1b / 569499	ZFINID:	ZDB-GENE-100805-1	Length:	1114	Species:	Danio rerio

Alignment Length:	1700	Identity:	382/1700 - (22%)
Similarity:	578/1700 - (34%)	Gaps:	671/1700 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 QTGRRHSCCSVMLP--VAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFT-----LSYI 102
            :|.||.|.|.   |  :|.|         .:||...||     ::|...|::...|     ||.:
Zfish    10 KTRRRRSHCP---PGTIACE---------DEFDCAELE-----ALFRRYRLKLEQTATLKALSVL 57

  Fly   103 LL--CSLMWCLYFVVDG-------GSEDFWRPISS-SFSMLSLVT-IMALCFTHWDLYREHRTVT 156
            :|  |||. .|..::.|       ||    .|:.| .|..|.:|| :..|..|.         :.
Zfish    58 ILLSCSLS-LLELLLSGTGLSVAQGS----HPVHSVLFISLFIVTNVQYLLVTQ---------LQ 108

  Fly   157 SAVTALLLCGASLAF----LTYTGRAFSPLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAF 217
            ......||.|.:.|.    |....||..|.......|.:..:.|..||:...|    |:.:.:..
Zfish   109 QIAHLSLLFGFTFAVPCCPLPQVSRAAGPEQGVWPLLLLTFMAYCLLPVRTGL----ALLFGLLL 169

  Fly   218 EMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSN-----RILILRIMAHLSVHLVGVHVLI 277
            .: :|.:|..|.:                      |.|     |.|:...:....|::.|:.|.|
Zfish   170 PL-AHTLITASTL----------------------PDNTQRLWRSLVANTLLFTGVNVSGLFVRI 211

  Fly   278 MNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVA-----DMLLNEGGPSGLDAGGL 337
            :.....|..|::....:..|.::|.|.:.:|:::.|::|..||     |.|             .
Zfish   212 LTERAQRKAFLQARNCIEERLRMEDENEKQERLLMSLLPRNVAMEMKEDFL-------------K 263

  Fly   338 PPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDD 402
            |||             .:|...::...:|||||||||||.|.::|..||::||::||:||.:||:
Zfish   264 PPE-------------RIFHKIYIQRHDNVSILFADIVGSTSLASQCTAQELVKLLNELFGKFDE 315

  Fly   403 LCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTG 467
            |.:.:.|.:|..||||||||||..:|:.|||.|||||||.|||.:..........:.||||:|||
Zfish   316 LATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTG 380

  Fly   468 TVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYF 532
            .||||::|.|:.::|||||||:|||.||:.|.|.:|||::.|...|...|.:|.|.
Zfish   381 RVLCGVLGLRKWQYDVWSNDVTLANMMEAGGLPGKVHITRSTLECLNGDYEVEPGN--------- 436

  Fly   533 VVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLN 597
              ||.|                          |...|.........|.|:.....| |.:.|.:.
Zfish   437 --GRER--------------------------HAFLLKHDIETFFIVPPHRRKIFP-GLILSDIK 472

  Fly   598 PSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVR----ERPKIIITTKSLP 658
            |:..:..:.....|...|..:...|             |.||...|:.    ::.:::   :|.|
Zfish   473 PAKKMKFKTVCYLLVQLMHCRKMFR-------------AEIPFSNVMNCEDGDKRRVL---RSAP 521

  Fly   659 GSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHL--- 720
            ..|.:......|.|...|..               ::.|::.|.  :..|.:...::...:|
Zfish   522 EKLRNRTPTAASAPQSSPGT---------------RVNRYINRL--IEARQTESDTADLNYLTLM 569

  Fly   721 --DKEREREREKEKEELHQHNQLNPE-----ETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTL 778
              |.||||          :::|||.|     ..|:.:              |.||:...:   .|
Zfish   570 YRDSERER----------RYHQLNDEYFTGAVVLSLL--------------LVVLLGFLY---LL 607

  Fly   779 DIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPF 843
            .||....||      ..|...:              |......||..|.
Zfish   608 IIPQGTVVL------VLLVFCI--------------CFLVVCIMYLHIT---------------- 636

  Fly   844 GRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLE 908
                  |.||
Zfish   637 ------RVQC------------------------------------------------------- 640

  Fly   909 PGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQT 973
                  .|.||               |...::::|                 ..|...|||:.|.
Zfish   641 ------FPGCL---------------TIQIRTALC-----------------VFIVLLIYAVAQA 667

  Fly   974 AISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDL 1038
            .:.......:.::||.||..:....||...:|.       :|...:|.|
Zfish   668 CVVGCMPWLWPSNSTRSIVIIDAAAGLNRTMAE-------LPCAGAQYA---------------- 709

  Fly  1039 QLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGPPTLATPRYNTY 1103

Zfish   710 ----------------------------------------------------------------- 709

  Fly  1104 IDIFVGIAVYLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSN 1168
                     :||                         |..|....||||
Zfish   710 ---------FLC-------------------------CMLGTLSMALFL---------------- 724

  Fly  1169 RFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLIIANFLL 1233
                                            |:     ||.|..|.|.:|:
Zfish   725 --------------------------------RV-----SWIPKTILLLLLL------------- 739

  Fly  1234 LDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVYSHNRSDQQ 1298
                           ::::.|:....|.:.:.|        |.|...|:
Zfish   740 ---------------VLYITILELSGFRRASGW--------ALLSVRGL---------------- 765

  Fly  1299 QDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMK 1363
                                |..|.|||....|...:|:.::..||.|.....|.:::..::.:|
Zfish   766 --------------------EPLLSLLLFSTAVALHSRQLDLKLRLDFLWATQAEEERDGMEKVK 810

  Fly  1364 NQADMLLHNIIPKHVAEHL-----KNTAKYSENHHNIAIIFASIVNFNEMYDESYLGGK----EF 1419
            .....:|.|::|.|||:|.     :|...|.:::..:.::||||.|||:.|.|  |.|.    |.
Zfish   811 LDNKRILFNLLPVHVAQHFLLSNPRNMDLYYQSYAQVGVLFASIPNFNDFYIE--LDGNNMGVEC 873

  Fly  1420 LRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDP-----SHRGTGDEHIHTLMEFSIA 1479
            ||:|||:|.|||||:.:..::.:|||||||||:|:|.||.|     :.:.|. .|:.|:.:|:|.
Zfish   874 LRLLNEIIADFDELMDKECYKDIEKIKTIGSTYMSAVGLVPTIGTKAKKSTA-THLSTIADFAIE 937

  Fly  1480 MQEVVDAFNKDLLEFN-LILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQV 1543
            |.:|:|..|..  .:| .:||:|:|:|.|.|||||..:..|||||:.|||||||||||:|.:|||
Zfish   938 MFDVLDEINYQ--SYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVPGKIQV 1000

  Fly  1544 GKDCLPFLTNRYEFEPRGSVYVKGKDHMEVFLYTTRRDNPLDDDEADKVEQLGTKKMEHEGRDED 1608
            .:|....|.|.|:...||:|.||||..|..:....:..:|            |.:...|.|..|.
Zfish  1001 TEDVYRLLQNNYDLMCRGNVSVKGKGQMLTYFLEGKAQDP------------GIRAPHHTGGLER 1053

  Fly  1609 VVQGEQQAEDKDEEEEEEEEDDDLHSSETTTLFKSQESLQANGGSHLAPNAAATSHTHTITLTNN 1673
            .|                      |:...|:..:::....::..|.||.....:|..|
Zfish  1054 RV----------------------HAIARTSSTQTKAGSVSSATSGLAVRVGLSSSFH------- 1089

  Fly  1674 NNHNSSNINN 1683
            ..|..||..|
Zfish  1090 GPHGHSNTTN 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	94/220 (43%)
		Guanylate_cyc	361..535	CDD:278633	85/173 (49%)
		CYCc	1362..1556	CDD:214485	91/208 (44%)
		Guanylate_cyc	1388..1575	CDD:278633	91/196 (46%)
adcy1b	NP_001161822.1	AC_N	<128..270	CDD:292831	36/194 (19%)
		CYCc	236..431	CDD:214485	94/220 (43%)
		Guanylate_cyc	272..454	CDD:278633	90/218 (41%)
		DUF1053	498..585	CDD:283888	22/116 (19%)
		CYCc	806..1012	CDD:214485	91/210 (43%)
		Guanylate_cyc	839..1035	CDD:278633	91/200 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810