DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and adcy7

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	XP_021333246.1	Gene:	adcy7 / 568726	ZFINID:	ZDB-GENE-040713-1	Length:	1119	Species:	Danio rerio

Alignment Length:	1618	Identity:	366/1618 - (22%)
Similarity:	565/1618 - (34%)	Gaps:	633/1618 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 DSPVLEEQYQASVFPHVRMRYRFTLSY---ILLCSLMWCLYFVVDGGSED---FWRPISSSFSML 133
            |...|:::.....|..:....:|.|..   |:.|:.:..|:|.....:::   |...:..:..:.
Zfish    10 DKQELKQEALYRKFSGISQYRQFVLLLGLSIVTCATLLVLFFSFKLKAQNHGIFVGVVGGALCLF 74

  Fly   134 SLVTIMALCFTHWDLYREHRTVTS-AVTAL-LLCGASLAFLTYTGRAFSPLGHFAICLEIVLLIY 196
            ..|.::....|   |.:..||:.. .|.|. |..|.:..|.|.:.....|.......|.|::.:|
Zfish    75 LAVFVLVCTET---LSQRWRTLLGLGVWATHLTMGFTFIFSTKSDLQIQPWDQVPFFLFIIITVY 136

  Fly   197 TALPMPLWLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILR 261
            |.||..:......:|..|::..:|..:.:..:.:|..|                       :..:
Zfish   137 TMLPFQMSYAVILSIISSLSHIIVLSVYLTVAQLHSNP-----------------------ITFQ 178

  Fly   262 IMAHLSVHLVGVHVLIMNLVRM----RGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVA-D 321
            ::::..|...|:.|.|.:.|.|    :.||....:.|.:|.:||:||:.:|.::.||:|..:: .
Zfish   179 LLSNAVVFGCGIMVGIFHKVLMEKALKQTFQDTLRCLGIRMKLEIEKRQQENLLQSVLPVYISMK 243

  Fly   322 MLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTA 386
            |.|     :.::......:....|....|:..||:...|    ||||||:||||||||::|..:.
Zfish   244 MKL-----AIMERCKCKDKEEQQRMVRDNNFHSLYVKRH----ENVSILYADIVGFTRLASDCSP 299

  Fly   387 EQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFD 451
            ::||.:||:||.:||.:...:.|.:|..||||||||||.|....:||..||:|||.|.:|::...
Zfish   300 KELVLMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPVSLPNHAKNCVKMGLDMCEAIKQVR 364

  Fly   452 AQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDA 516
            ......:.||||||:|.||||::|.|:.:|||||:||:|||.|||.|.|.:|||::.|...|..|
Zfish   365 EATGVDINMRVGVHSGNVLCGVIGLRKWQFDVWSHDVTLANHMESGGLPGRVHITEATLKHLNKA 429

  Fly   517 YYLEEGEEVFGH-----------RTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLS 570
            |.:|||.   ||           :|:.|:..|                :..|||:.|
Zfish   430 YEVEEGN---GHLRDTYLKELNIKTFLVIDPR----------------SKDSSLMAP-------- 467

  Fly   571 QSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAA 635
                  |..:|.|                          |..:|||
Zfish   468 ------SITKPRV--------------------------SDGLKMR------------------- 481

  Fly   636 AGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLK 700
            |.:                                                       ::.|||:
Zfish   482 ASV-------------------------------------------------------RMTRFLE 491

  Fly   701 RFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQL 765
                     |.|......||....|                       |..:.|.||.|
Zfish   492 ---------SWGAVKPFAHLQSREE-----------------------FNTDAMVNGKG------ 518

  Fly   766 PVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVR 830
                      ...|||              |.|....:|::                :|:
Zfish   519 ----------HCKDIP--------------LRSVPTHNPDS----------------FDE----- 538

  Fly   831 SYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRAS 895

Zfish   539 ----------------------------------------------------------------- 538

  Fly   896 TLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRR 960
                      |||      .|..||||..|         |::|                 :.|::
Zfish   539 ----------SLE------EPFSLPAPPLS---------TYNR-----------------NKSQK 561

  Fly   961 SSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPL 1025
            :...::::....|.|:.       .||:.......|:.||
Zfish   562 TKFDEELHDKMTTTIND-------LSSSKQWVKSEEISGL------------------------- 594

  Fly  1026 AACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETE 1090
                                                  :|:|..:.||..:|
Zfish   595 --------------------------------------TLWFTKKDLEMQYR------------- 608

  Fly  1091 GPPTLATPRYNTYIDIFVGIA--VYLCISVSLFLMTQNTVSPSFRLWVTLFSCF----------- 1142
               |:..|.:..||    |.|  :::||.:...|:|:..:  ...|...:.:||
Zfish   609 ---TIEMPNFKYYI----GCATFIFICIFIIQMLVTKQRI--ELGLGFAVLACFLLLILCICFAD 664

  Fly  1143 --------------------------------------TGIQVFALF-LFTRQMCRRQSGSNVSN 1168
                                                  |.|.|.|:| ||.::.      .|:.:
Zfish   665 HIQRMFPEKLKSCTWLLALSKAVVKRPFVRILLATVATTVIVVIAMFELFLKKT------DNLCD 723

  Fly  1169 RFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLIIANFLL 1233
            ..:..|:.: |..|||....|                    |..:.|:..|:|..|.|.:
Zfish   724 LLQQNSSFA-DSARDELQYLP--------------------YLVYNCILALIACGVFLRV----- 762

  Fly  1234 LDLEQLEAFEYHYGFLIFVCIVHFC--------NFTQLNCWVRNVLAFLAALCFIGIAVSQLMVY 1290
                   :||....||:.|.:|.:.        .|:..||     |.:....|...:.|.:..:.
Zfish   763 -------SFELKLAFLLIVSLVSYTIILYSQENLFSNYNC-----LLYTNHSCGDSLMVCKAGLM 815

  Fly  1291 SHNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQD 1355
            .|.:            |...         ||:.|.|..:|:  ::|:.|...|..|........|
Zfish   816 KHPK------------IMSC---------IYITLFLFTMLL--ISRQNEYCCRQDFLLKNKNLAD 857

  Fly  1356 KVRVQNMKNQADMLLHNIIPKHVA-----EHLKN-----------TAKYSENHHN----IAIIFA 1400
            |..|:..:|...:||.|::|.|||     |:.||           ..||.:.::.    :.::||
Zfish   858 KEEVELCENLNRLLLENVLPAHVAALFVGENKKNEVGLLSAISLLNRKYKDLYYKSYDCVCVMFA 922

  Fly  1401 SIVNFNEMYDESYLG--GKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLD-PSH 1462
            |:.:|.|.|.|..:.  |.|.||:|||:|.|||||||:|:|..||||||||||:|||:||. |..
Zfish   923 SVPDFKEFYTECDINKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAAAGLSGPPE 987

  Fly  1463 RGTGDE-----HIHTLMEFSIAMQEVVDAFNKDLLEFNLI-LRIGMNIGDVTAGVIGTSKLYYDI 1521
            :...|.     .|..::||:||:...:|..|:.  .||.. ||:|:|.|.|.|||||..|..|||
Zfish   988 QSNQDRERQNAQIGNMVEFAIALIGKLDGINRH--SFNTFRLRVGINHGPVIAGVIGARKPQYDI 1050

  Fly  1522 WGDAVNVASRMDSTGLPNRIQVGKDCLPFLTN-RYEFEPRGSVYVKGKDHMEVFLYTT 1578
            ||:.|||||||:|||...:|||.::....|.| .|..|.||.:.||||..::.|...|
Zfish  1051 WGNTVNVASRMESTGELGKIQVTEETSIVLQNLGYSCECRGLINVKGKGELKTFFVCT 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	92/216 (43%)
		Guanylate_cyc	361..535	CDD:278633	87/184 (47%)
		CYCc	1362..1556	CDD:214485	95/223 (43%)
		Guanylate_cyc	1388..1575	CDD:278633	91/200 (46%)
adcy7	XP_021333246.1	AC_N	<129..248	CDD:318454	31/146 (21%)
		Guanylate_cyc	272..455	CDD:306677	88/189 (47%)
		DUF1053	487..613	CDD:310728	45/401 (11%)
		Guanylate_cyc	909..1106	CDD:306677	91/198 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810