Protein Alignment Ac13E and adcy2a

DIOPT Version :10

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_692173.5
• Gene: adcy2a / 563724
• ZFINID: ZDB-GENE-061109-1
• Length: 1155
• Species: Danio rerio
• Alignment Length: 1624
• Identity: 356/1624 - (21%)
• Similarity: 567/1624 - (34%)
• Gaps: 674/1624 - (41%)

  Fly    63 RAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILL------CSLMWCLYFVVDGGSED 121
            |..:..||   :||             :.||..:..|...||      |..:..::|......||
Zfish    85 RQRSPDWL---YDS-------------YHRMSQQHPLIVFLLLIVMGACLALLAVFFASGLDIED 133

  Fly   122 FWRPISSSFSMLSLVTIMALCFTHW------DLYREHRTVTSAVTALLLCGASLAFL-TYTGRAF 179
                 ..:| ::::.|.:|:..|.:      .::::...|.|.|  :..|..::.:| .:.|...
Zfish   134 -----HVAF-VITVPTALAIFLTIFVLVCIESVFKKLLRVFSLV--IWGCLVAMGYLFMFFGGII 190

  Fly   180 SPLGHFAICLEIVLLIYTALPM----PLWLGASTAISYSIAFEM-----VSHMVIGCSAIHGGPM 235
            .|....:..|.|:.::||.||.    .:.....||.|:::...:     |||:
Zfish   191 CPWDQVSFFLFIIFVVYTMLPFSMRDAIIASVLTASSHTVVLSVCLSSTVSHV------------ 243

  Fly   236 HGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVG-----VHVLIMNLVRMRGTFMKVGQNLL 295
                            :|    |:.:|:|::.:.:.|     .|..:|.|. ::.|:......:.
Zfish   244 ----------------EP----LVWQILANVIIFICGNVAGAYHKHLMELA-LKQTYQDTCNCIK 287

  Fly   296 VRRQLEMEKQLKEKMIHSVMPPKVADMLLNE-----GGPSGLDAGGLPPESHYMRPRASNDVKSL 355
            ...:||.||:.:|:::.|::|..:|.::..|     .||.            :.:...:|:..:|
Zfish   288 SPIKLEFEKRQQERLLLSLLPAHIARVMKAEIIQRLQGPK------------FGQVENTNNFHNL 340

  Fly   356 FRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYY 420
            :...|    .|||||:||||||||::|..:..:||.:||:||.:||.:...:.|.:|..||||||
Zfish   341 YVQRH----TNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYY 401

  Fly   421 CVSGCPEPRADHAICCVEMGLGMIDAM-RCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVW 484
            ||||.||...:||..||:|||.|.:|: :..||...| :.||||||:|.||||::|.::.::|||
Zfish   402 CVSGLPESLPNHAKNCVKMGLDMCEAIKKVRDATGVE-ISMRVGVHSGNVLCGVIGLQKWQYDVW 465

  Fly   485 SNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYFVVGRRRDFTRTNSLSPS 549
            |:||:|||.||:.|.|.:|||:.||...|..||.:|:|.           |:.||        |.
Zfish   466 SHDVTLANHMEAGGVPGRVHITSETLEHLNGAYKVEDGH-----------GQERD--------PY 511

  Fly   550 MPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMK 614
            :..:...:.|:                  :.|.|.            ..||....|||.|....|
Zfish   512 LKEHGVITYLV------------------INPKVE------------RKSPQHYYRPRHTIDGAK 546

  Fly   615 MRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANP 679
            ||
Zfish   547 MR--------------------------------------------------------------- 548

  Fly   680 PAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPE 744
              |..|....|:.|..   .|.|.:|.:|.|
Zfish   549 --ASVRMTRYLESWGA---AKPFANLHHRDS---------------------------------- 574

  Fly   745 ETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVS 809
                     |.|.||              :..|.|:|.
Zfish   575 ---------MTNENG--------------KINTADVPI--------------------------- 589

  Fly   810 GGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGR 874
                    |||..            |.||:
Zfish   590 --------GQYHF------------QRRSE----------------------------------- 599

  Fly   875 AGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQ 939
                                                                             
Zfish   600 ----------------------------------------------------------------- 599

  Fly   940 SSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPL 1004
                           ::.|::...:::   ||:
Zfish   600 ---------------RTKSQKKRFEEE---LNE-------------------------------- 614

  Fly  1005 AVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVR--DNARSQRSYLVKPPLRKFSLYF 1067
                                                 |.:|  |...||:.:|....:::.||:|
Zfish   615 -------------------------------------RMIRTFDGINSQKQWLKSEDIQRISLFF 642

  Fly  1068 KSRQLERDFRSKAHRFGAENETEGPPTLATPRYNTYIDIFVGIAVYLCISVSLFLMTQNT--VSP 1130
            .::.||:::|:              .||  |.:..||.  ....::.||.:...|:...|  :..
Zfish   643 HNKALEKEYRA--------------TTL--PAFKYYIT--CACLIFFCIFIVQILVLPKTAILGV 689

  Fly  1131 SFR-----LWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPG 1190
            ||.     |.|.|..||.|
Zfish   690 SFGMSFLILSVILLVCFIG---------------------------------------------- 708

  Fly  1191 GRPHFESCADRIFEAISSWY------------PWHICLAVLMAMPVLLIIANFLLLDLEQ----- 1238
               ||..|..   .|.:||.            ||......:....::||:|.|.:..:|.
Zfish   709 ---HFLQCKK---TASASWVWILRSSGIIASKPWPRITLTMATTALILIMAVFNMFFIEDNLTLM 767

  Fly  1239 ---------------------LEAFEYHYGFLIFVCIVHF--CN-FTQLNCWVRNVLAFLAALCF 1279
                                 |:...::..:.|:.||:..  |: |.::|..::.::...|.:.:
Zfish   768 ETVYNTSNETLLQPDGQPIPYLDKNTFYLPYFIYSCILGLISCSVFLRINYELKMLIMLTAVVLY 832

  Fly  1280 IGIAVSQLMVYSHNRSDQQQDQ--------EASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNR 1336
                 |.:::.:|.....:..:        |....::::|......:.|:...||:|.      |
Zfish   833 -----SVIILQTHASLLDEYSKFLYKTEVIERPGVLKDLKTMGSVSLFIFFITLLVLA------R 886

  Fly  1337 EFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHL-----KNTAKYSENHHNIA 1396
            :.|...||.|.......::...::.|:|...:||.|::|.|||||.     ||...|.:::..:.
Zfish   887 QNEYYCRLDFLWKNKFKKECEEIETMENLNRVLLENVLPAHVAEHFLARNWKNEDLYHQSYDLVC 951

  Fly  1397 IIFASIVNFNEMYDESYLG--GKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLD 1459
            ::||||.:|.|.|.||.:.  |.|.||:|||:|.|||||||:|:|..||||||||||:|||:||:
Zfish   952 VMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLN 1016

  Fly  1460 ----PSHRGTGDE---HIHTLMEFSIAMQEVVDAFNKDLLEFN-LILRIGMNIGDVTAGVIGTSK 1516
                |.:....|.   ||.|::||:.|:...:|..||.  .|| ..||:|:|.|.|.|||||..|
Zfish  1017 ATPGPEYTQEHDRQYMHIGTMVEFAFALVGKLDVINKH--SFNDFKLRVGINHGPVKAGVIGAQK 1079

  Fly  1517 LYYDIWGDAVNVASRMDSTGLPNRIQVGKD--CLPFLTNRYEFEPRGSVYVKGKDHMEVFLYTT 1578
            ..|||||:.|||||||||||:..:|||.::  |: ..|..|....||.:.||||..::.:...|
Zfish  1080 PQYDIWGNTVNVASRMDSTGVLGKIQVTEETSCI-LQTLGYTCSCRGIINVKGKGELKTYFVHT 1142

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	92/221 (42%)
		PHA03307	836..>1015	CDD:223039	5/178 (3%)
		Guanylate_cyc	1388..1575	CDD:425528	95/198 (48%)
adcy2a	XP_692173.5	AcyC	104..529	CDD:441717	143/531 (27%)
		Guanylate_cyc	340..524	CDD:425528	90/225 (40%)
		Adcy_cons_dom	554..659	CDD:461877	38/414 (9%)
		Guanylate_cyc	942..1141	CDD:425528	95/201 (47%)