Protein Alignment Ac13E and adcy5

DIOPT Version :9

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_001165056.1
• Gene: adcy5 / 562619
• ZFINID: ZDB-GENE-081104-470
• Length: 1186
• Species: Danio rerio
• Alignment Length: 1654
• Identity: 370/1654 - (22%)
• Similarity: 563/1654 - (34%)
• Gaps: 647/1654 - (39%)

  Fly     3 ESRRQSVSSRAMPPGVL--------VNDSRANSTDDIQIALAPHIQTYLSQTGRRHSCCSVMLPV 59
            |||..:.||.....|.:        :.|.|..|..:.:  |.|.:...:|      :||:.::.:
Zfish    89 ESRNNNRSSPRYRDGEVRPKSVELGLEDRRTKSKPEEE--LMPEVNFSMS------ACCNSVMQI 145

  Fly    60 AFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLS----------YILLCSLMWCLYFV 114
                     :...||.|..||..||         ||.|.|:          .:|:|::|  |.|.
Zfish   146 ---------FRSKKFQSEKLERLYQ---------RYFFRLNQSSLTMLMAVLVLVCAVM--LGFH 190

  Fly   115 VDGGSEDFWRPISSSFSMLSLVTIMALCFTHWDLYREHRTVTSAVTALLLCGASLAFLTYTGRAF 179
            ..||.......:..:.:::.::|:|.:|..: ..:::|..:...:..||:....:..:.:.....
Zfish   191 CAGGMCQLTFVLVFTAAIVLILTLMVVCNRN-SFHQDHMWIVCYLLILLVLAVQVVGVLFVKPRS 254

  Fly   180 SPLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVSH-----------------MVIGC 227
            :..|.:.... .:.:|||.||:.:.....|.|..|....::|.                 ::..|
Zfish   255 ASEGIWWTVF-FIHVIYTLLPVRMRAAVITGIILSAIHVLISWRLNDMDVFLWKQLVSNVLIFSC 318

  Fly   228 SAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQ 292
            |.|.|...|          ..|.|.                              .|..|.:..:
Zfish   319 SNIVGVCTH----------YPAEGS------------------------------QRQAFQETRE 343

  Fly   293 NLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKS--- 354
            .:..|...:.|.|.:|:::.||:|..||                       :..:|..:.|.
Zfish   344 CIQARLHSQRENQQQERLLLSVLPRHVA-----------------------LEMKADINAKQEDM 385

  Fly   355 LFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCY 419
            :|...::...:|||||||||.|||.::|..||::||..||:||.|||.|.:.:.|.:|..|||||
Zfish   386 MFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCY 450

  Fly   420 YCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVW 484
            |||||.||.|||||.||||||:.||:|:..........|.||||:|:|.|.||::|.|:.:||||
Zfish   451 YCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVW 515

  Fly   485 SNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVFGHR----------TYFVVGRRRD 539
            ||||:|||.||:.||..::||::.|.::|...|.:|.|..  |.|          ||.:||..:.
Zfish   516 SNDVTLANHMEAGGKAGRIHITKATLNYLNGDYDVEPGSG--GERNVYLKKHNIETYLIVGCSQK 578

  Fly   540 FTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSM 604
            .....::...|....|               .|.|:.|....:.|       ..:.||.:.|
Zfish   579 RKEEKAMIAKMNRQRT---------------NSVTHNSTHWTDRP-------FYNHLNANSV--- 618

  Fly   605 RPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPV 669
                 |..||.......:|::.:..:
Zfish   619 -----SKEMKRMGFEDPKDKNTQENL--------------------------------------- 639

  Fly   670 SPPLLPPANPP---------AAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKERE 725
                    ||.         |.:.||..:|:...:.:||..|
Zfish   640 --------NPEDEVDEFLGRAIDARSIDRLRSEHVKKFLLTF----------------------- 673

  Fly   726 REREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHA 790
            ||.:.||:...|                               |:|:.
Zfish   674 REPDLEKKYSKQ-------------------------------VDSSF----------------- 690

  Fly   791 ATSTALAS---------SVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRS 846
            ....|.||         .::..|.:|:       ..|.|.:...::.|..:||...|
Zfish   691 GAYVACASLVFLFICFIQIIIVPHSGL-------MVGFYVLCLVVLMVVMFISAIYS-------- 740

  Fly   847 GSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGP 911
                                                                             
Zfish   741 ----------------------------------------------------------------- 740

  Fly   912 SSTSPCCLPAPGNSVGGGGIFP-PTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAI 975
                  |.          |.|| |..:....|..|                       .||.|.:
Zfish   741 ------CF----------GFFPIPLQTLSKRIVQS-----------------------RLNSTLV 766

  Fly   976 SQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQL 1040
            ....:...|.|:..:|.                       .||:   |.|..||.|....|...:
Zfish   767 GVFTIVLVFISAFINIF-----------------------TCST---DDLKTCLGQEFNISPSNV 805

  Fly  1041 IRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGPPTLATPRYNTYID 1105
            ..|                                   .|| |.:.|.|
Zfish   806 NAC-----------------------------------HAH-FSSLNYT---------------- 818

  Fly  1106 IFVGIAVYLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNRF 1170
                            |.:||                             ::|
Zfish   819 ----------------LWSQN-----------------------------RLC------------ 826

  Fly  1171 RSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLIIAN----F 1231
            .|.|.|....|            :|.||.                |..|:|..|.|.:::    |
Zfish   827 NSSSPTCNFPE------------YFSSCV----------------LLSLLACSVFLQVSSIGKLF 863

  Fly  1232 LLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWV-RNVLAFLAALCFIGIAVSQLMVYSHNRS 1295
            |:|.:|.|        :::.:.:.....|..::..| .|.||.....|.:...|...:|..
Zfish   864 LMLFIEIL--------YVLIMEVPEVSLFDNVDLLVMANALAPNNGTCIVDTRVPLKIVTP---- 916

  Fly  1296 DQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLN-REFEIGYRLTFYGNAVANQDKVRV 1359
                                       .::.:.||..:|: ::.|...||.|.....|.::|..:
Zfish   917 ---------------------------VVITVFVLALYLHAQQVESTARLDFLWKLQATEEKEEM 954

  Fly  1360 QNMKNQADMLLHNIIPKHVAEHL-----KNTAKYSENHHNIAIIFASIVNFNEMYDESYLG--GK 1417
            :.::.....|||||:||.||.|.     :|...|.::...:|::||||.||:|.|.|....  |.
Zfish   955 EELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASISNFSEFYVELEANNEGV 1019

  Fly  1418 EFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGL-DPSHRGTGDEHIHTLMEFSIAMQ 1481
            |.||:|||:|.||||::|..:||.:|||||||||:|||||| |.::...|..||..|.::::.:.
Zfish  1020 ECLRLLNEIIADFDEIISEDQFRQLEKIKTIGSTYMAASGLNDSTYDKAGRSHIRALADYAMRLM 1084

  Fly  1482 EVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKD 1546
            :.:...|:.... |..::||:|:|.|.|||||..|..|||||:.|||||||||||:|.||||..|
Zfish  1085 DQMKYINEHSFN-NFKMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPERIQVTTD 1148

  Fly  1547 CLPFLTN-RYEFEPRGSVYVKGKDHMEVF 1574
            ....|:: .|..|.||.|.||||..|..:
Zfish  1149 LYQVLSSYNYTLEYRGVVKVKGKGEMMTY 1177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	95/218 (44%)
		Guanylate_cyc	361..535	CDD:278633	91/183 (50%)
		CYCc	1362..1556	CDD:214485	93/202 (46%)
		Guanylate_cyc	1388..1575	CDD:278633	92/191 (48%)
adcy5	NP_001165056.1	AC_N	1..388	CDD:292831	68/391 (17%)
		CYCc	354..548	CDD:214485	95/216 (44%)
		Guanylate_cyc	390..574	CDD:278633	91/185 (49%)
		DUF1053	598..687	CDD:283888	24/204 (12%)
		CYCc	961..1155	CDD:214485	93/194 (48%)
		Guanylate_cyc	987..1181	CDD:278633	92/192 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810